Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 3616722..3618442 Replicon chromosome
Accession NZ_CP082215
Organism Xanthomonas cucurbitae strain MI_359

Toxin (Protein)


Gene name pmenT Uniprot ID -
Locus tag K6982_RS15395 Protein ID WP_104602389.1
Coordinates 3616722..3617372 (+) Length 217 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID -
Locus tag K6982_RS15400 Protein ID WP_159407552.1
Coordinates 3617372..3618442 (+) Length 357 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6982_RS15370 (K6982_15295) 3612639..3613289 + 651 WP_159407550.1 SGNH/GDSL hydrolase family protein -
K6982_RS15375 (K6982_15300) 3613296..3613697 + 402 WP_159407551.1 hypothetical protein -
K6982_RS15380 (K6982_15305) 3613838..3614509 + 672 WP_104602386.1 methyltransferase -
K6982_RS15385 (K6982_15310) 3614709..3615500 - 792 WP_208800396.1 polysaccharide deacetylase family protein -
K6982_RS15390 (K6982_15315) 3615546..3616472 + 927 WP_104602388.1 Grx4 family monothiol glutaredoxin -
K6982_RS15395 (K6982_15320) 3616722..3617372 + 651 WP_104602389.1 DUF4433 domain-containing protein Toxin
K6982_RS15400 (K6982_15325) 3617372..3618442 + 1071 WP_159407552.1 macro domain-containing protein Antitoxin
K6982_RS15405 (K6982_15330) 3618544..3619104 - 561 WP_104602391.1 DUF924 family protein -
K6982_RS15410 (K6982_15335) 3619244..3620644 + 1401 WP_159407553.1 amidohydrolase -
K6982_RS15415 (K6982_15340) 3620641..3621921 + 1281 WP_159407554.1 amidohydrolase family protein -
K6982_RS15420 (K6982_15345) 3622068..3622883 - 816 Protein_3029 cellulase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3605271..3618442 13171


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(16-216)

Antitoxin

Macro domain

(18-130)


Sequences

Toxin        


Download         Length: 217 a.a.        Molecular weight: 25041.42 Da        Isoelectric Point: 7.2475

>T214381 WP_104602389.1 NZ_CP082215:3616722-3617372 [Xanthomonas cucurbitae]
MSRRYLNLNPDKALIWRIVHRDNLPWILDNGLHCGNGSARSPGWVSIGNPELIDKRACHPVPLTPGGFLNDYVPFYFTPF
SPMLRNIQTGWGGIQQRANDEIVILVSSLHHVKARGWPFLFTDSHAYYQLTTFHSDLTNLDTIDWSLIQARDFRRDQEDP
AKFERYQAEALVHRHLPVDGLLGIVCYTDDMKRSIERQLEARNLALSVHARTEWYF

Download         Length: 651 bp

>T214381 NZ_CP110059:2759143-2759292 [Enterococcus faecalis]
ATGCGTATGCACGTATTTCCGAAATTTAGAGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACGATCCTAGG
GTTTGGTATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 357 a.a.        Molecular weight: 39768.68 Da        Isoelectric Point: 6.2605

>AT214381 WP_159407552.1 NZ_CP082215:3617372-3618442 [Xanthomonas cucurbitae]
MITFTQGNLLQARVEALVNTVNTVGVMGKGIALMFKERFNENFLRYAAACKAKEVQIGKMFVTATSELDGPRWIINFPTK
QHWRGDSRIEWITDGLQDLRLFLIENKVESIAIPPLGAGNGGLDWADVRPLIEEALAGLDTNILVFEPTPRYQNVAKRSG
VEKLTPARALIAELVRRYLVLGVECSLLEIQKLAWFLERNIERAGLPTLDLRFAPHRYGPYTDRLRHLLDGLDGSYLHCD
KRIGDADPLDVIWFDDSRKSFVQSYLKSEAKQYAPALEATAALIDGFESPFGMELLATIDWLVVREGISAQVADIREGIR
HWPGGPDAAARKDRLFNDRALGIALERLTSHAAAAS

Download         Length: 1071 bp

>AT214381 NZ_CP110059:c2759409-2759225 [Enterococcus faecalis]
TGCTACAATAGAGACGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCTTTTTA
GTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCA
ATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References