Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/COG3657-dnstrm_HI1420
Location 2268320..2268936 Replicon chromosome
Accession NZ_CP082214
Organism Xanthomonas cucurbitae strain OH_261

Toxin (Protein)


Gene name PumA Uniprot ID A0A853FWE4
Locus tag K6978_RS10040 Protein ID WP_048279626.1
Coordinates 2268320..2268616 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag K6978_RS10045 Protein ID WP_048279629.1
Coordinates 2268622..2268936 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6978_RS10010 (K6978_09990) 2263378..2263602 + 225 WP_104605634.1 hypothetical protein -
K6978_RS10015 (K6978_09995) 2263872..2264663 + 792 WP_104605632.1 P-type conjugative transfer protein TrbJ -
K6978_RS10020 (K6978_10000) 2264666..2264848 + 183 WP_004690111.1 hypothetical protein -
K6978_RS10025 (K6978_10005) 2264851..2266476 + 1626 WP_274397155.1 P-type conjugative transfer protein TrbL -
K6978_RS10030 (K6978_10010) 2266510..2267460 + 951 WP_159406945.1 IS30 family transposase -
K6978_RS10035 (K6978_10015) 2267548..2267874 + 327 WP_032422605.1 hypothetical protein -
K6978_RS10040 (K6978_10020) 2268320..2268616 + 297 WP_048279626.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6978_RS10045 (K6978_10025) 2268622..2268936 + 315 WP_048279629.1 putative addiction module antidote protein Antitoxin
K6978_RS10050 (K6978_10030) 2269137..2269889 - 753 WP_104604572.1 ABC transporter ATPase -
K6978_RS10055 (K6978_10035) 2269876..2270757 - 882 WP_104604570.1 helicase RepA family protein -
K6978_RS10060 (K6978_10040) 2270761..2270991 - 231 WP_104604568.1 AlpA family phage regulatory protein -
K6978_RS10065 (K6978_10045) 2271276..2272484 - 1209 WP_016941853.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2258684..2280391 21707


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(45-91)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11147.01 Da        Isoelectric Point: 10.4422

>T214376 WP_048279626.1 NZ_CP082214:2268320-2268616 [Xanthomonas cucurbitae]
MIELIKTDLFDRWLVGLRDRQARARIEARIRRLSLGNPGDVKPVGEGLSEMRIDHGPGYRVYFMRRGPLVVLLLCGGDKS
SQERDIALAKTIAAQWKE

Download         Length: 297 bp

>T214376 NZ_CP110059:c343982-343887 [Enterococcus faecalis]
ATGTACGAGATTGTCACAAAAATTCTTGTGCCGATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGTTGGAAAA
ACAGAACAAGGAATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 10802.21 Da        Isoelectric Point: 4.7393

>AT214376 WP_048279629.1 NZ_CP082214:2268622-2268936 [Xanthomonas cucurbitae]
MEVKFSRYDTADYLKTEDDIAAYLDAVMEDGDPALIAAALGDVARARNLSQLARDVGMSRQGLDKALSGDGNPSLATVVK
VAQALGLRLTFKPTHGGPAPAAGA

Download         Length: 315 bp

>AT214376 NZ_CP110059:343788-343852 [Enterococcus faecalis]
CTTGTGACAAAGTCGTGCATGGATGCACTAAAAAGACACCCTATTGTGGTAGGGTGTCTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853FWE4

Antitoxin

Source ID Structure

References