Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) EcnAB/-
Location 191538..191902 Replicon chromosome
Accession NZ_CP082214
Organism Xanthomonas cucurbitae strain OH_261

Toxin (Protein)


Gene name EcnB Uniprot ID A0A0B2CMD0
Locus tag K6978_RS00910 Protein ID WP_016904515.1
Coordinates 191768..191902 (+) Length 45 a.a.

Antitoxin (Protein)


Gene name EcnA Uniprot ID H8FG64
Locus tag K6978_RS00905 Protein ID WP_003486606.1
Coordinates 191538..191690 (+) Length 51 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6978_RS00875 (K6978_00890) 186538..187218 - 681 WP_274396771.1 dTMP kinase -
K6978_RS00880 (K6978_00895) 187758..188297 - 540 WP_104601872.1 ATP/GTP-binding protein -
K6978_RS00885 (K6978_00900) 188294..189211 - 918 WP_104601871.1 hypothetical protein -
K6978_RS00890 (K6978_00905) 189306..189665 - 360 WP_104601870.1 hypothetical protein -
K6978_RS00895 (K6978_00910) 189733..190185 - 453 WP_104601869.1 roadblock/LC7 domain-containing protein -
K6978_RS00900 (K6978_00915) 190505..191428 + 924 WP_104602004.1 arginase -
K6978_RS00905 (K6978_00920) 191538..191690 + 153 WP_003486606.1 entericidin A/B family lipoprotein Antitoxin
K6978_RS00910 (K6978_00925) 191768..191902 + 135 WP_016904515.1 entericidin A/B family lipoprotein Toxin
K6978_RS00915 (K6978_00930) 192136..192345 + 210 WP_104601868.1 CsbD family protein -
K6978_RS00920 (K6978_00935) 192500..193789 + 1290 WP_167526971.1 tryptophan--tRNA ligase -
K6978_RS00925 (K6978_00940) 193873..194811 + 939 WP_274396772.1 MBL fold metallo-hydrolase -
K6978_RS00930 (K6978_00945) 194899..196551 + 1653 WP_170066936.1 M28 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Entericidin A/B

(23-42)

Antitoxin

Entericidin A/B

(23-42)


Sequences

Toxin        


Download         Length: 45 a.a.        Molecular weight: 4443.26 Da        Isoelectric Point: 9.3487

>T214374 WP_016904515.1 NZ_CP082214:191768-191902 [Xanthomonas cucurbitae]
MKRAIVLLVLSVLSVGMLSGCNTVAGAGKDVQGAGEKVEDAARK

Download         Length: 135 bp

>T214374 NZ_CP110055:19695-20036 [Enterococcus faecalis]
ATGAGTGACGAAAAGAAATATATTCCTAAAAAGGGCGATATTGTATGGATAGATTTCGATCCTTCAGCTGAAAAAGAAAT
ACAGAAAAGACGTCCAGGTCTAGTAGTTTCTAGATATGAGTTTAATAGAAAGACATTGTTTGCAGTAATTTGTCCCATAA
CTTCTACAATTAAAAATATGCCAACTCGTTATACATTACCTGATGAAATGGAAACTCATGGACAAGTCGTTATTTCCCAA
TTAAAATCTTTAGACTTTGCAGAAAGAAAGTTAAGCCAAATAGAATATTTACCATTAAAGGATATGGCTAAAATAGATCA
AATCATTGAATACATTTTTTAA

Antitoxin


Download         Length: 51 a.a.        Molecular weight: 5122.07 Da        Isoelectric Point: 8.7942

>AT214374 WP_003486606.1 NZ_CP082214:191538-191690 [Xanthomonas cucurbitae]
MKRLLTLMVLGLFSAGVMTGCNTVAGAGKDMQGAGNKVEKTAEKCSDGKC

Download         Length: 153 bp

>AT214374 NZ_CP110055:19465-19695 [Enterococcus faecalis]
ATGTTAACCACAAAATCTAGAAAACAAGGAAGTTCTGTAGTATTGACATTACCATCTAATAACGGACAGAAACCAAAAGC
AGACCAAGAATATATAGTAATGTATTCTGATGATGGGACAATTACGTTAGTCCCTAAATTACAAGACCCATTTAGTGGTG
GATCAGAAGGGGAGTACTACGAAAAAGATGAATGGCATGACATTGAACCTGGAGGGAGAGAATTATTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B2CMD0

Antitoxin

Source ID Structure
AlphaFold DB A0A828YLX6

References