Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) EcnAB/-
Location 191566..191930 Replicon chromosome
Accession NZ_CP082213
Organism Xanthomonas cucurbitae strain WI_206

Toxin (Protein)


Gene name EcnB Uniprot ID A0A0B2CMD0
Locus tag K6981_RS00915 Protein ID WP_016904515.1
Coordinates 191796..191930 (+) Length 45 a.a.

Antitoxin (Protein)


Gene name EcnA Uniprot ID H8FG64
Locus tag K6981_RS00910 Protein ID WP_003486606.1
Coordinates 191566..191718 (+) Length 51 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6981_RS00880 (K6981_00895) 186566..187246 - 681 WP_274396771.1 dTMP kinase -
K6981_RS00885 (K6981_00900) 187786..188325 - 540 WP_104601872.1 ATP/GTP-binding protein -
K6981_RS00890 (K6981_00905) 188322..189239 - 918 WP_104601871.1 hypothetical protein -
K6981_RS00895 (K6981_00910) 189334..189693 - 360 WP_104601870.1 hypothetical protein -
K6981_RS00900 (K6981_00915) 189761..190213 - 453 WP_104601869.1 roadblock/LC7 domain-containing protein -
K6981_RS00905 (K6981_00920) 190533..191456 + 924 WP_104602004.1 arginase -
K6981_RS00910 (K6981_00925) 191566..191718 + 153 WP_003486606.1 entericidin A/B family lipoprotein Antitoxin
K6981_RS00915 (K6981_00930) 191796..191930 + 135 WP_016904515.1 entericidin A/B family lipoprotein Toxin
K6981_RS00920 (K6981_00935) 192164..192373 + 210 WP_104601868.1 CsbD family protein -
K6981_RS00925 (K6981_00940) 192528..193817 + 1290 WP_167526971.1 tryptophan--tRNA ligase -
K6981_RS00930 (K6981_00945) 193901..194839 + 939 WP_274396772.1 MBL fold metallo-hydrolase -
K6981_RS00935 (K6981_00950) 194927..196579 + 1653 WP_170066936.1 M28 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Entericidin A/B

(23-42)

Antitoxin

Entericidin A/B

(23-42)


Sequences

Toxin        


Download         Length: 45 a.a.        Molecular weight: 4443.26 Da        Isoelectric Point: 9.3487

>T214369 WP_016904515.1 NZ_CP082213:191796-191930 [Xanthomonas cucurbitae]
MKRAIVLLVLSVLSVGMLSGCNTVAGAGKDVQGAGEKVEDAARK

Download         Length: 135 bp

>T214369 NZ_CP110054:2759078-2759227 [Enterococcus faecalis]
ATGCGTATGCACGTATTTCCGAAATTTAGAGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACGATCCTAGG
GTTTGGTATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 51 a.a.        Molecular weight: 5122.07 Da        Isoelectric Point: 8.7942

>AT214369 WP_003486606.1 NZ_CP082213:191566-191718 [Xanthomonas cucurbitae]
MKRLLTLMVLGLFSAGVMTGCNTVAGAGKDMQGAGNKVEKTAEKCSDGKC

Download         Length: 153 bp

>AT214369 NZ_CP110054:c2759344-2759160 [Enterococcus faecalis]
TGCTACAATAGAGACGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCTTTTTA
GTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCA
ATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B2CMD0

Antitoxin

Source ID Structure
AlphaFold DB A0A828YLX6

References