Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4134746..4135365 Replicon chromosome
Accession NZ_CP082212
Organism Klebsiella pneumoniae strain BJ20

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag K6039_RS20565 Protein ID WP_002892050.1
Coordinates 4135147..4135365 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag K6039_RS20560 Protein ID WP_002892066.1
Coordinates 4134746..4135120 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6039_RS20550 (K6039_20500) 4129898..4131091 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
K6039_RS20555 (K6039_20505) 4131114..4134260 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit AcrB -
K6039_RS20560 (K6039_20510) 4134746..4135120 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
K6039_RS20565 (K6039_20515) 4135147..4135365 + 219 WP_002892050.1 HHA domain-containing protein Toxin
K6039_RS20570 (K6039_20520) 4135524..4136090 + 567 WP_002892030.1 maltose O-acetyltransferase -
K6039_RS20575 (K6039_20525) 4136062..4136202 - 141 WP_004147370.1 hypothetical protein -
K6039_RS20580 (K6039_20530) 4136223..4136693 + 471 WP_002892026.1 YlaC family protein -
K6039_RS20585 (K6039_20535) 4136668..4138119 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
K6039_RS20590 (K6039_20540) 4138220..4138918 + 699 WP_002892021.1 GNAT family protein -
K6039_RS20595 (K6039_20545) 4138915..4139055 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
K6039_RS20600 (K6039_20550) 4139055..4139318 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T214364 WP_002892050.1 NZ_CP082212:4135147-4135365 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T214364 NZ_CP110054:c343978-343883 [Enterococcus faecalis]
ATGTACGAGATTGTCACAAAAATTCTTGTGCCGATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGTTGGAAAA
ACAGAACAAGGAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT214364 WP_002892066.1 NZ_CP082212:4134746-4135120 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT214364 NZ_CP110054:343784-343848 [Enterococcus faecalis]
CTTGTGACAAAGTCGTGCATGGATGCACTAAAAAGACACCCTATTGTGGTAGGGTGTCTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References