Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4954266..4955947 Replicon chromosome
Accession NZ_CP082211
Organism Klebsiella pneumoniae strain A1718

Toxin (Protein)


Gene name mosT Uniprot ID -
Locus tag K6036_RS23860 Protein ID WP_004178299.1
Coordinates 4954266..4955183 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag K6036_RS23865 Protein ID WP_004177809.1
Coordinates 4955189..4955947 (-) Length 253 a.a.

Genomic Context


K6036_RS23840K6036_RS23845K6036_RS23850K6036_RS23855K6036_RS23875K6036_RS23885K6036_RS23860K6036_RS23865K6036_RS23870K6036_RS23880
Location: 4949572..4951092 (1521 bp)
Type: Others
Protein ID: WP_002885173.1
Location: 4951089..4952087 (999 bp)
Type: Others
Protein ID: WP_002885172.1
Location: 4952118..4953059 (942 bp)
Type: Others
Protein ID: WP_002885156.1
Location: 4953134..4954141 (1008 bp)
Type: Others
Protein ID: WP_004178300.1
Location: 4957034..4959181 (2148 bp)
Type: Others
Protein ID: WP_012737173.1
Location: 4959759..4960445 (687 bp)
Type: Others
Protein ID: WP_004151733.1
Location: 4954266..4955183 (918 bp)
Type: Toxin
Protein ID: WP_004178299.1
Location: 4955189..4955947 (759 bp)
Type: Antitoxin
Protein ID: WP_004177809.1
Location: 4956033..4956761 (729 bp)
Type: Others
Protein ID: WP_004178298.1
Location: 4959178..4959321 (144 bp)
Type: Others
Protein ID: WP_022631365.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K6036_RS23840 (4949572)4949572..4951092+1521WP_002885173.1sugar ABC transporter ATP-binding protein-
K6036_RS23845 (4951089)4951089..4952087+999WP_002885172.1ribose ABC transporter permease-
K6036_RS23850 (4952118)4952118..4953059+942WP_002885156.1ABC transporter substrate-binding protein-
K6036_RS23855 (4953134)4953134..4954141+1008WP_004178300.1carbohydrate kinase family protein-
K6036_RS23860 (4954266)4954266..4955183-918WP_004178299.1nucleotidyl transferase AbiEii/AbiGii toxin family proteinToxin
K6036_RS23865 (4955189)4955189..4955947-759WP_004177809.1type IV toxin-antitoxin system AbiEi family antitoxinAntitoxin
K6036_RS23870 (4956033)4956033..4956761-729WP_004178298.1response regulator transcription factor-
K6036_RS23875 (4957034)4957034..4959181+2148WP_012737173.1formate dehydrogenase H subunit alpha, selenocysteine-containing-
K6036_RS23880 (4959178)4959178..4959321-144WP_022631365.1hypothetical protein-
K6036_RS23885 (4959759)4959759..4960445+687WP_004151733.1tetratricopeptide repeat protein-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 306 a.a.        Molecular weight: 34649.06 Da        Isoelectric Point: 5.4707

>T214349 WP_004178299.1 NZ_CP082211:c4955183-4954266 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPSQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

>T214349 NZ_CP110050:2485422-2485811 [Enterococcus faecalis]
GTGGATTTTATTAGTAAAGAACTCTATTTTGAAGCATTTAATTTTTCGAACGAATTAATAAAAGAAGTATCATACTACTC
TTCCAAAAATATTGAACAAGTTAAATGCTTTGATATTGAAAAATATGTAAAAGAAGTTGAAGATGTTGAATTTGTTGAAT
ACACGTTTCAAAAACAACTTAAAAGACGGATGCTTGGTTCAATCTCTAAAGTAGACGATGAAGTCATTATAACAACAAAC
AAAGAATTAATGTTAGAACGAAAAAATTTCACTAAAATGCATGAGGTTATACATTACTACATAGATATACCTAAAATTAA
TAATGCAACTCATACTTTTTCTGATATTCTTTTAAAAAATGGTTACTTGATGGAAGATTTTCCAAAATAA

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT214349 WP_004177809.1 NZ_CP082211:c4955947-4955189 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp

>AT214349 NZ_CP110050:2485021-2485407 [Enterococcus faecalis]
GTGACTATTATTAAAACAAATGAACGTTTGAAACAACTACGTGAAAATAAAGAATTAACTCAAAAAGAATTAGCTGATTT
ACTACACATGGATAGAAGTGTTTATAATAAAATTGAATCAGGTGCTCGTCCCATTCGTGATAACGAACTAATTCAATTTG
CGGATTTCTATAATGTATCAACAGACTACCTTACAAATAGAACTAACAATCCCATTCCCCCTGAAGAAAAAACAAATGTG
GGACAAAATATCATCTCACATTTTCGTCTAAATACTTCTGATATGGACATAGAAGATATAGAAGAATTAGAAGAAGAATT
AATCGACTTTCAAGATTTTCTTATAAAAAAAGCAAAAGAAAAAAAGGAACGTAACAAAAAAGATTGA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
No matching records found


Antitoxin

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Source
ID
Structure
AlphaFold DBA6TH05

References