Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
Location | 4954266..4955947 | Replicon | chromosome |
Accession | NZ_CP082211 | ||
Organism | Klebsiella pneumoniae strain A1718 |
Toxin (Protein)
Gene name | mosT | Uniprot ID | - |
Locus tag | K6036_RS23860 | Protein ID | WP_004178299.1 |
Coordinates | 4954266..4955183 (-) | Length | 306 a.a. |
Antitoxin (Protein)
Gene name | mosA | Uniprot ID | A6TH05 |
Locus tag | K6036_RS23865 | Protein ID | WP_004177809.1 |
Coordinates | 4955189..4955947 (-) | Length | 253 a.a. |
Genomic Context
Location: 4949572..4951092 (1521 bp)
Type: Others
Protein ID: WP_002885173.1
Type: Others
Protein ID: WP_002885173.1
Location: 4951089..4952087 (999 bp)
Type: Others
Protein ID: WP_002885172.1
Type: Others
Protein ID: WP_002885172.1
Location: 4952118..4953059 (942 bp)
Type: Others
Protein ID: WP_002885156.1
Type: Others
Protein ID: WP_002885156.1
Location: 4953134..4954141 (1008 bp)
Type: Others
Protein ID: WP_004178300.1
Type: Others
Protein ID: WP_004178300.1
Location: 4957034..4959181 (2148 bp)
Type: Others
Protein ID: WP_012737173.1
Type: Others
Protein ID: WP_012737173.1
Location: 4959759..4960445 (687 bp)
Type: Others
Protein ID: WP_004151733.1
Type: Others
Protein ID: WP_004151733.1
Location: 4954266..4955183 (918 bp)
Type: Toxin
Protein ID: WP_004178299.1
Type: Toxin
Protein ID: WP_004178299.1
Location: 4955189..4955947 (759 bp)
Type: Antitoxin
Protein ID: WP_004177809.1
Type: Antitoxin
Protein ID: WP_004177809.1
Location: 4956033..4956761 (729 bp)
Type: Others
Protein ID: WP_004178298.1
Type: Others
Protein ID: WP_004178298.1
Location: 4959178..4959321 (144 bp)
Type: Others
Protein ID: WP_022631365.1
Type: Others
Protein ID: WP_022631365.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
K6036_RS23840 (4949572) | 4949572..4951092 | + | 1521 | WP_002885173.1 | sugar ABC transporter ATP-binding protein | - |
K6036_RS23845 (4951089) | 4951089..4952087 | + | 999 | WP_002885172.1 | ribose ABC transporter permease | - |
K6036_RS23850 (4952118) | 4952118..4953059 | + | 942 | WP_002885156.1 | ABC transporter substrate-binding protein | - |
K6036_RS23855 (4953134) | 4953134..4954141 | + | 1008 | WP_004178300.1 | carbohydrate kinase family protein | - |
K6036_RS23860 (4954266) | 4954266..4955183 | - | 918 | WP_004178299.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
K6036_RS23865 (4955189) | 4955189..4955947 | - | 759 | WP_004177809.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
K6036_RS23870 (4956033) | 4956033..4956761 | - | 729 | WP_004178298.1 | response regulator transcription factor | - |
K6036_RS23875 (4957034) | 4957034..4959181 | + | 2148 | WP_012737173.1 | formate dehydrogenase H subunit alpha, selenocysteine-containing | - |
K6036_RS23880 (4959178) | 4959178..4959321 | - | 144 | WP_022631365.1 | hypothetical protein | - |
K6036_RS23885 (4959759) | 4959759..4960445 | + | 687 | WP_004151733.1 | tetratricopeptide repeat protein | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
No matching records found |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 306 a.a. Molecular weight: 34649.06 Da Isoelectric Point: 5.4707
>T214349 WP_004178299.1 NZ_CP082211:c4955183-4954266 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPSQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPSQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
Download Length: 918 bp
>T214349 NZ_CP110050:2485422-2485811 [Enterococcus faecalis]
GTGGATTTTATTAGTAAAGAACTCTATTTTGAAGCATTTAATTTTTCGAACGAATTAATAAAAGAAGTATCATACTACTC
TTCCAAAAATATTGAACAAGTTAAATGCTTTGATATTGAAAAATATGTAAAAGAAGTTGAAGATGTTGAATTTGTTGAAT
ACACGTTTCAAAAACAACTTAAAAGACGGATGCTTGGTTCAATCTCTAAAGTAGACGATGAAGTCATTATAACAACAAAC
AAAGAATTAATGTTAGAACGAAAAAATTTCACTAAAATGCATGAGGTTATACATTACTACATAGATATACCTAAAATTAA
TAATGCAACTCATACTTTTTCTGATATTCTTTTAAAAAATGGTTACTTGATGGAAGATTTTCCAAAATAA
GTGGATTTTATTAGTAAAGAACTCTATTTTGAAGCATTTAATTTTTCGAACGAATTAATAAAAGAAGTATCATACTACTC
TTCCAAAAATATTGAACAAGTTAAATGCTTTGATATTGAAAAATATGTAAAAGAAGTTGAAGATGTTGAATTTGTTGAAT
ACACGTTTCAAAAACAACTTAAAAGACGGATGCTTGGTTCAATCTCTAAAGTAGACGATGAAGTCATTATAACAACAAAC
AAAGAATTAATGTTAGAACGAAAAAATTTCACTAAAATGCATGAGGTTATACATTACTACATAGATATACCTAAAATTAA
TAATGCAACTCATACTTTTTCTGATATTCTTTTAAAAAATGGTTACTTGATGGAAGATTTTCCAAAATAA
Antitoxin
Download Length: 253 a.a. Molecular weight: 28548.92 Da Isoelectric Point: 10.0870
>AT214349 WP_004177809.1 NZ_CP082211:c4955947-4955189 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
Download Length: 759 bp
>AT214349 NZ_CP110050:2485021-2485407 [Enterococcus faecalis]
GTGACTATTATTAAAACAAATGAACGTTTGAAACAACTACGTGAAAATAAAGAATTAACTCAAAAAGAATTAGCTGATTT
ACTACACATGGATAGAAGTGTTTATAATAAAATTGAATCAGGTGCTCGTCCCATTCGTGATAACGAACTAATTCAATTTG
CGGATTTCTATAATGTATCAACAGACTACCTTACAAATAGAACTAACAATCCCATTCCCCCTGAAGAAAAAACAAATGTG
GGACAAAATATCATCTCACATTTTCGTCTAAATACTTCTGATATGGACATAGAAGATATAGAAGAATTAGAAGAAGAATT
AATCGACTTTCAAGATTTTCTTATAAAAAAAGCAAAAGAAAAAAAGGAACGTAACAAAAAAGATTGA
GTGACTATTATTAAAACAAATGAACGTTTGAAACAACTACGTGAAAATAAAGAATTAACTCAAAAAGAATTAGCTGATTT
ACTACACATGGATAGAAGTGTTTATAATAAAATTGAATCAGGTGCTCGTCCCATTCGTGATAACGAACTAATTCAATTTG
CGGATTTCTATAATGTATCAACAGACTACCTTACAAATAGAACTAACAATCCCATTCCCCCTGAAGAAAAAACAAATGTG
GGACAAAATATCATCTCACATTTTCGTCTAAATACTTCTGATATGGACATAGAAGATATAGAAGAATTAGAAGAAGAATT
AATCGACTTTCAAGATTTTCTTATAAAAAAAGCAAAAGAAAAAAAGGAACGTAACAAAAAAGATTGA
Structures
Toxin
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Source | ID | Structure |
---|---|---|
No matching records found |
Antitoxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A6TH05 |