Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4708913..4709748 Replicon chromosome
Accession NZ_CP082211
Organism Klebsiella pneumoniae strain A1718

Toxin (Protein)


Gene name yeeV Uniprot ID A0A5E2RWI0
Locus tag K6036_RS22690 Protein ID WP_001559913.1
Coordinates 4708913..4709290 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A5E3EVB5
Locus tag K6036_RS22695 Protein ID WP_032408847.1
Coordinates 4709380..4709748 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6036_RS22650 (4704178) 4704178..4704444 + 267 WP_004178415.1 hypothetical protein -
K6036_RS22655 (4704444) 4704444..4705116 + 673 Protein_4444 DUF4400 domain-containing protein -
K6036_RS22660 (4705127) 4705127..4705843 + 717 WP_223203127.1 RES domain-containing protein -
K6036_RS22665 (4706211) 4706211..4706399 - 189 Protein_4446 transposase -
K6036_RS22670 (4706416) 4706416..4707527 - 1112 Protein_4447 IS3 family transposase -
K6036_RS22675 (4707977) 4707977..4708126 - 150 Protein_4448 restriction endonuclease subunit M -
K6036_RS22680 (4708211) 4708211..4708408 - 198 WP_032408848.1 DUF957 domain-containing protein -
K6036_RS22685 (4708428) 4708428..4708916 - 489 WP_001559914.1 DUF5983 family protein -
K6036_RS22690 (4708913) 4708913..4709290 - 378 WP_001559913.1 TA system toxin CbtA family protein Toxin
K6036_RS22695 (4709380) 4709380..4709748 - 369 WP_032408847.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
K6036_RS22700 (4709925) 4709925..4710146 - 222 WP_000692300.1 DUF987 domain-containing protein -
K6036_RS22705 (4710215) 4710215..4710691 - 477 WP_032408846.1 RadC family protein -
K6036_RS22710 (4710706) 4710706..4711191 - 486 WP_088607457.1 antirestriction protein -
K6036_RS22715 (4711283) 4711283..4712101 - 819 WP_001559911.1 DUF932 domain-containing protein -
K6036_RS22720 (4712201) 4712201..4712434 - 234 WP_001119729.1 DUF905 family protein -
K6036_RS22725 (4712513) 4712513..4712968 - 456 WP_000581504.1 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4697290..4727704 30414


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14148.10 Da        Isoelectric Point: 7.8276

>T214347 WP_001559913.1 NZ_CP082211:c4709290-4708913 [Klebsiella pneumoniae]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T214347 NZ_CP110050:606651-606767 [Enterococcus faecalis]
ATGTTTTTGTCCGTTGAAGCAGCGCTAGGACTGATGATTGGTTTTGCAACACTTGTTGTGACCATTATCTTCGGTATCTT
AGCGCTTGTCTTAGACAACAAAAATAACCGTTCATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13682.62 Da        Isoelectric Point: 7.8398

>AT214347 WP_032408847.1 NZ_CP082211:c4709748-4709380 [Klebsiella pneumoniae]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVMLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT214347 NZ_CP110050:c606883-606678 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5E2RWI0

Antitoxin

Source ID Structure
AlphaFold DB A0A5E3EVB5

References