Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4036024..4036643 Replicon chromosome
Accession NZ_CP082211
Organism Klebsiella pneumoniae strain A1718

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag K6036_RS19495 Protein ID WP_002892050.1
Coordinates 4036425..4036643 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag K6036_RS19490 Protein ID WP_002892066.1
Coordinates 4036024..4036398 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6036_RS19480 (4031176) 4031176..4032369 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
K6036_RS19485 (4032392) 4032392..4035538 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
K6036_RS19490 (4036024) 4036024..4036398 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
K6036_RS19495 (4036425) 4036425..4036643 + 219 WP_002892050.1 HHA domain-containing protein Toxin
K6036_RS19500 (4036802) 4036802..4037368 + 567 WP_002892030.1 maltose O-acetyltransferase -
K6036_RS19505 (4037340) 4037340..4037480 - 141 WP_004147370.1 hypothetical protein -
K6036_RS19510 (4037501) 4037501..4037971 + 471 WP_002892026.1 YlaC family protein -
K6036_RS19515 (4037946) 4037946..4039380 - 1435 Protein_3832 PLP-dependent aminotransferase family protein -
K6036_RS19520 (4039481) 4039481..4040179 + 699 WP_002892021.1 GNAT family protein -
K6036_RS19525 (4040176) 4040176..4040316 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
K6036_RS19530 (4040316) 4040316..4040579 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T214345 WP_002892050.1 NZ_CP082211:4036425-4036643 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T214345 NZ_CP110050:c317921-317826 [Enterococcus faecalis]
ATGTACGAGATTGTCACAAAAATTCTTGTGCCGATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGTTGGAAAA
ACAGAACGAGGAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT214345 WP_002892066.1 NZ_CP082211:4036024-4036398 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT214345 NZ_CP110050:317727-317791 [Enterococcus faecalis]
CTTGTGACAAAGTCGTGCATGGATGCACTAAAAAGACACCCTATTGTGGTAGGGTGTCTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References