Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2740580..2742168 Replicon chromosome
Accession NZ_CP082211
Organism Klebsiella pneumoniae strain A1718

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag K6036_RS13315 Protein ID WP_004179815.1
Coordinates 2740580..2741902 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag K6036_RS13320 Protein ID WP_004176198.1
Coordinates 2741902..2742168 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6036_RS13300 (2735636) 2735636..2738137 + 2502 WP_020323802.1 fimbria/pilus outer membrane usher protein -
K6036_RS13305 (2738125) 2738125..2739129 + 1005 WP_004179822.1 fimbrial protein -
K6036_RS13310 (2739271) 2739271..2740563 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
K6036_RS13315 (2740580) 2740580..2741902 - 1323 WP_004179815.1 type II toxin-antitoxin system HipA family toxin Toxin
K6036_RS13320 (2741902) 2741902..2742168 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
K6036_RS13325 (2742434) 2742434..2742760 - 327 WP_002904788.1 hydroxyisourate hydrolase -
K6036_RS13330 (2742757) 2742757..2743257 - 501 WP_004179811.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
K6036_RS13335 (2743235) 2743235..2744614 - 1380 WP_004179808.1 nucleobase:cation symporter-2 family protein -
K6036_RS13340 (2744960) 2744960..2746114 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
K6036_RS13345 (2746095) 2746095..2747018 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - mgtC / iroE 2534385..2777003 242618


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49152.42 Da        Isoelectric Point: 7.2850

>T214343 WP_004179815.1 NZ_CP082211:c2741902-2740580 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T214343 NZ_CP110048:7244-7354 [Enterococcus faecalis]
GTGTTATTTGTGAAAGATTTAATGTCGTTGGTTATCGCACCGATCTTTGTAGGATTGGTTCTGGAAATGATTTCTCGTGT
GTTGGACGAGGAAGACGATAACCGAAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT214343 WP_004176198.1 NZ_CP082211:c2742168-2741902 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT214343 NZ_CP110048:c7458-7394 [Enterococcus faecalis]
AACGACATTAAATCGTACAAATAACACAAAAAGCAATCCTACGGCGAATAGGATTGCTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References