Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 855477..856134 Replicon chromosome
Accession NZ_CP082211
Organism Klebsiella pneumoniae strain A1718

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag K6036_RS04255 Protein ID WP_002916310.1
Coordinates 855724..856134 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag K6036_RS04250 Protein ID WP_002916312.1
Coordinates 855477..855743 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6036_RS04225 (850633) 850633..852066 - 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -
K6036_RS04230 (852185) 852185..852913 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
K6036_RS04235 (852963) 852963..853274 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
K6036_RS04240 (853438) 853438..854097 + 660 WP_002916317.1 hemolysin III family protein -
K6036_RS04245 (854248) 854248..855231 - 984 WP_020324927.1 tRNA-modifying protein YgfZ -
K6036_RS04250 (855477) 855477..855743 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
K6036_RS04255 (855724) 855724..856134 + 411 WP_002916310.1 protein YgfX Toxin
K6036_RS04260 (856141) 856141..856662 - 522 WP_004144730.1 flavodoxin FldB -
K6036_RS04265 (856763) 856763..857659 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
K6036_RS04270 (857682) 857682..858395 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K6036_RS04275 (858401) 858401..860134 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T214334 WP_002916310.1 NZ_CP082211:855724-856134 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T214334 NZ_CP110047:c317924-317829 [Enterococcus faecalis]
ATGTACGAGATTGTCACAAAAATTCTTGTGCCGATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGTTGGAAAA
ACAGAACGAGGAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT214334 WP_002916312.1 NZ_CP082211:855477-855743 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT214334 NZ_CP110047:317730-317794 [Enterococcus faecalis]
CTTGTGACAAAGTCGTGCATGGATGCACTAAAAAGACACCCTATTGTGGTAGGGTGTCTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References