Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4813087..4813603 Replicon chromosome
Accession NZ_CP082207
Organism Klebsiella pneumoniae strain KPN43G

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag K6032_RS23225 Protein ID WP_009486548.1
Coordinates 4813087..4813371 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag K6032_RS23230 Protein ID WP_002886901.1
Coordinates 4813361..4813603 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6032_RS23200 (4808483) 4808483..4808791 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
K6032_RS23205 (4808876) 4808876..4809049 + 174 WP_004222159.1 hypothetical protein -
K6032_RS23210 (4809052) 4809052..4809795 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
K6032_RS23215 (4810152) 4810152..4812290 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
K6032_RS23220 (4812619) 4812619..4813083 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
K6032_RS23225 (4813087) 4813087..4813371 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6032_RS23230 (4813361) 4813361..4813603 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K6032_RS23235 (4813681) 4813681..4815591 - 1911 WP_004152270.1 PRD domain-containing protein -
K6032_RS23240 (4815614) 4815614..4816768 - 1155 WP_004178372.1 lactonase family protein -
K6032_RS23245 (4816835) 4816835..4817575 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T214324 WP_009486548.1 NZ_CP082207:c4813371-4813087 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T214324 NZ_CP110041:563053-563169 [Enterococcus faecalis]
ATGTTTTTGTCCGTTGAAGCAGCGCTAGGACTGATGATTGGTTTTGCAACACTTGTTGTGACCATTATCTTCGGTATCTT
AGCGCTTGTCTTAGACAACAAAAATAACCGTTCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT214324 WP_002886901.1 NZ_CP082207:c4813603-4813361 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT214324 NZ_CP110041:c563285-563080 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References