Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4115568..4116187 Replicon chromosome
Accession NZ_CP082207
Organism Klebsiella pneumoniae strain KPN43G

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag K6032_RS19885 Protein ID WP_002892050.1
Coordinates 4115969..4116187 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag K6032_RS19880 Protein ID WP_002892066.1
Coordinates 4115568..4115942 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6032_RS19870 (4110720) 4110720..4111913 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
K6032_RS19875 (4111936) 4111936..4115082 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
K6032_RS19880 (4115568) 4115568..4115942 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
K6032_RS19885 (4115969) 4115969..4116187 + 219 WP_002892050.1 HHA domain-containing protein Toxin
K6032_RS19890 (4116346) 4116346..4116912 + 567 WP_002892030.1 maltose O-acetyltransferase -
K6032_RS19895 (4116884) 4116884..4117024 - 141 WP_004147370.1 hypothetical protein -
K6032_RS19900 (4117045) 4117045..4117515 + 471 WP_002892026.1 YlaC family protein -
K6032_RS19905 (4117490) 4117490..4118941 - 1452 WP_004177237.1 PLP-dependent aminotransferase family protein -
K6032_RS19910 (4119042) 4119042..4119740 + 699 WP_004177238.1 GNAT family protein -
K6032_RS19915 (4119737) 4119737..4119877 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
K6032_RS19920 (4119877) 4119877..4120140 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T214322 WP_002892050.1 NZ_CP082207:4115969-4116187 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T214322 NZ_CP110040:2651029-2651172 [Enterococcus faecalis]
ATGAATGTAAGTGCTAAAATCTATGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGG
TATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT214322 WP_002892066.1 NZ_CP082207:4115568-4115942 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT214322 NZ_CP110040:c2651330-2651105 [Enterococcus faecalis]
AGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTATAATGGTAATGAAAAGAGAGATATGCTGTAACAT
ACCTCTCTAGTGTAGAGCCGTTTCAGACGGTGACCTTTTTAGTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTT
ATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References