Detailed information of TA system TA214309

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 2204617..2205103
• Replicon: chromosome
• Accession: NZ_CP082206
• Organism: Streptococcus dysgalactiae strain DY107

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q48QR0
• Locus tag: K6973_RS10855
• Protein ID: WP_014407961.1
• Coordinates: 2204617..2204886 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A660A1J7
• Locus tag: K6973_RS10860
• Protein ID: WP_014407962.1
• Coordinates: 2204876..2205103 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K6973_RS10840 (K6973_10840)	2200115..2201188	+	1074	WP_218654947.1	DUF4097 family beta strand repeat-containing protein	-
K6973_RS10845 (K6973_10845)	2201312..2203585	-	2274	WP_222819402.1	YhgE/Pip domain-containing protein	-
K6973_RS10850 (K6973_10850)	2203720..2204253	+	534	WP_003059589.1	TetR/AcrR family transcriptional regulator	-
K6973_RS10855 (K6973_10855)	2204617..2204886	-	270	WP_014407961.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K6973_RS10860 (K6973_10860)	2204876..2205103	-	228	WP_014407962.1	DUF6290 family protein	Antitoxin
K6973_RS10865 (K6973_10865)	2205254..2205625	-	372	WP_222819403.1	ArpU family phage packaging/lysis transcriptional regulator	-
K6973_RS10870 (K6973_10870)	2205600..2205962	-	363	WP_192942666.1	DUF1492 domain-containing protein	-
K6973_RS10875 (K6973_10875)	2206234..2206455	-	222	WP_222819724.1	hypothetical protein	-
K6973_RS10880 (K6973_10880)	2206455..2206703	-	249	WP_261987941.1	hypothetical protein	-
K6973_RS10885 (K6973_10885)	2206693..2207031	-	339	WP_037580661.1	hypothetical protein	-
K6973_RS10890 (K6973_10890)	2207114..2207362	-	249	WP_222819404.1	hypothetical protein	-
K6973_RS10895 (K6973_10895)	2207372..2208157	-	786	WP_222819405.1	hypothetical protein	-
K6973_RS10900 (K6973_10900)	2208247..2208396	-	150	WP_222819406.1	hypothetical protein	-
K6973_RS10905 (K6973_10905)	2208409..2208654	-	246	WP_222819407.1	hypothetical protein	-
K6973_RS10910 (K6973_10910)	2208650..2208976	-	327	Protein_2116	hypothetical protein	-
K6973_RS10915 (K6973_10915)	2209157..2209330	-	174	WP_000694580.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-87)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10497.50 Da
• Isoelectric Point: 10.5027

>T214309 WP_014407961.1 NZ_CP082206:c2204886-2204617 [Streptococcus dysgalactiae]
MTYKLVVSDEVKKQLKKMDKHVGLMLAKDMKKRLDGLNNPRQFGKALTGQYKGLWRYRVGNYRVICDIVDNEMIILALEV
GHRKEIYKR

Nucleotide

• Length: 270 bp

>T214309 NZ_CP110036:131883-132026 [Enterococcus faecalis]
ATGAGCGTACTTCCAAAATTTACAGAAAGGAGAGGCCTGTTGTCAGCATATGAGACAATTCAGACGATCCTAGGTTTTGG
TATGTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8641.63 Da
• Isoelectric Point: 3.9607

>AT214309 WP_014407962.1 NZ_CP082206:c2205103-2204876 [Streptococcus dysgalactiae]
MAMVSLRLNSAEEELFRSYATHTGKTLSELFKTALAQQIEDQLDYETGIQALKRFEENPITYSIDDLIEELENDL

Nucleotide

• Length: 228 bp

>AT214309 NZ_CP110036:c132145-131959 [Enterococcus faecalis]
TGTGCTAGAATGTAGATGAAAAGAGAGATATGCGTCAACATACCTCTCTAGTGTAGAGCCGTTTGAGACGGTGACCGATT
GTATTATTTAAAAATAACCGTACTGGTCAAAGTAGATGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGTG
CAATCAAAGCAATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: A0A660A202

Antitoxin

• AlphaFold DB: A0A660A1J7