Detailed information of TA system TA214308

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 2175958..2176444
• Replicon: chromosome
• Accession: NZ_CP082206
• Organism: Streptococcus dysgalactiae strain DY107

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: K6973_RS10730
• Protein ID: WP_222819395.1
• Coordinates: 2176175..2176444 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: K6973_RS10725
• Protein ID: WP_222819394.1
• Coordinates: 2175958..2176185 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K6973_RS10700 (K6973_10700)	2171361..2171465	-	105	Protein_2072	RhuM family protein	-
K6973_RS10705 (K6973_10705)	2172630..2173457	-	828	WP_218654931.1	EbhA	-
K6973_RS11370	2173920..2174429	-	510	WP_261987938.1	helix-turn-helix domain-containing protein	-
K6973_RS10715 (K6973_10715)	2174641..2175198	+	558	WP_222819392.1	hypothetical protein	-
K6973_RS10720 (K6973_10720)	2175272..2175760	+	489	WP_222819393.1	hypothetical protein	-
K6973_RS10725 (K6973_10725)	2175958..2176185	+	228	WP_222819394.1	DUF6290 family protein	Antitoxin
K6973_RS10730 (K6973_10730)	2176175..2176444	+	270	WP_222819395.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K6973_RS10735 (K6973_10735)	2177495..2180566	+	3072	WP_222819396.1	serum opacification factor	-
K6973_RS11375	2180801..2180938	+	138	Protein_2080	IS3 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-87)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10433.39 Da
• Isoelectric Point: 10.2939

>T214308 WP_222819395.1 NZ_CP082206:2176175-2176444 [Streptococcus dysgalactiae]
MTYKLVISDDVKKQLKKMDKYVALMLAKDMKKQLDNLSNPRQIGKALTGQYKGLWRYRIGNYRVVCDIIDNELVTIALEV
GHRKDIYKK

Nucleotide

• Length: 270 bp

>T214308 NZ_CP110036:57892-58233 [Enterococcus faecalis]
ATGAACGTTGAAAAGAAGTACATTCCCAAAAAAGGAGATATTGTATGGATTGATTTTGATCCTGCTGCAGGTAAAGAAAT
TCAGAAGAGACGGCCTGGTTTAGTCGTGTCAAGATATGAATTTAATCGGAAAACCATGTTTGCTGTGATTTGCCCGATTA
CTTCCACCATTAAAAATATTCCCACTCGATATACGTTGCCCGATGACATAGAAACCCAAGGACAAGTAGTGATCTCACAA
CTGAAATCTTTGGACTTCACTGAAAGAAAATTAAGTCAAATTGAGCATTTGCCATTAAAAGATATGGCGAAAATTGACCA
AATAATTGAATATATTTTCTAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8848.95 Da
• Isoelectric Point: 4.2808

>AT214308 WP_222819394.1 NZ_CP082206:2175958-2176185 [Streptococcus dysgalactiae]
MTTISLRLNEQEEKLFKSYSFHTGKTLSELFKTSLKEQIEDQLDYEVGIQALERFEKNPVTHNIDDIIMELENDL

Nucleotide

• Length: 228 bp

>AT214308 NZ_CP110036:57662-57892 [Enterococcus faecalis]
ATGCTAACAACTAAATCAAGAAGACAAGGAAGCTCGGTCGTTTTAACTTTACCCACTGATAATGGTAAAAAACCAAAAGT
CGACCAAGAATATATTGTGATGTATTCTGACGACGGTACAATTACATTAGTCCCTAAAATTCAGGATCCATTTAGTGAAG
GCCCAGAAGGTGAGTATTATGAAAAAGATGAGTGGCATGATCTTGCACCTGAGGGGAGAGAACTTTTTTAA