Detailed information of TA system TA214307

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 1441839..1443271
• Replicon: chromosome
• Accession: NZ_CP082206
• Organism: Streptococcus dysgalactiae strain DY107

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: G7SFZ4
• Locus tag: K6973_RS07360
• Protein ID: WP_001030299.1
• Coordinates: 1442426..1443271 (+)
• Length: 282 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: G7SFZ3
• Locus tag: K6973_RS07355
• Protein ID: WP_000037237.1
• Coordinates: 1441839..1442429 (+)
• Length: 197 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K6973_RS07355 (K6973_07355)	1441839..1442429	+	591	WP_000037237.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
K6973_RS07360 (K6973_07360)	1442426..1443271	+	846	WP_001030299.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
K6973_RS07365 (K6973_07365)	1443334..1446135	-	2802	WP_000656693.1	phage tail tip lysozyme	-
K6973_RS07370 (K6973_07370)	1446137..1447018	-	882	Protein_1416	type IV secretion system protein VirB4	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	cat / aph(3')-III / ant(6)-Ia / aac(6')-aph(2'') / lnu(B) / lsa(E) / erm(B) / tet(O)	-	1390174..1459073	68899

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-258)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (6-50)

Sequences

Toxin

Protein

• Length: 282 a.a.
• Molecular weight: 32462.14 Da
• Isoelectric Point: 5.4404

>T214307 WP_001030299.1 NZ_CP082206:1442426-1443271 [Streptococcus dysgalactiae]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSSYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQITLSEE
TVKQQLKEILADSEEGISFVIQSITAIKESDDYGGYRATISCQLENIKQVIHLDIATGDVVTPQPITYDYKAIFDEDNFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKEDIDFIQLRNACQRTFSYRETELDFVKIIELLERFKSDP
IQNKQWQNYSKKYSYTKGISLADVLDEMIRLITVLISINSD

Nucleotide

• Length: 846 bp

>T214307 NZ_CP110036:c52452-52303 [Enterococcus faecalis]
ATGCGTATGCACGTATTTCCGAAATTTAGAGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACAATTCTTGG
GTTTGGTATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin

Protein

• Length: 197 a.a.
• Molecular weight: 23056.59 Da
• Isoelectric Point: 7.8056

>AT214307 WP_000037237.1 NZ_CP082206:1441839-1442429 [Streptococcus dysgalactiae]
MSKKEILLDFIEKNNGIVTNKDCKALGIPTIYLTRLEKEGIIFRVEKGIFLTQNGDYDEYYFFQYRFPKAIFSYISALYL
QQFTDEIPQYFDVTVPRGYRFNTPPANLNIHFVSKEYSELGMTTVPTPLGNNVRVYDFERIICDFVIHREKIDSELFVKT
LQSYGNYPKKNLAKLYEYATKMNTLEKVKQTLEVLI

Nucleotide

• Length: 591 bp

>AT214307 NZ_CP110036:52186-52370 [Enterococcus faecalis]
TGCTACAATAGAGACGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCTTTTTA
GTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCA
ATCAAAGCAATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: G7SFZ4

Antitoxin

• AlphaFold DB: G7SFZ3