Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1993988..1994594 Replicon chromosome
Accession NZ_CP082203
Organism Streptococcus suis strain NJ3

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag K6972_RS09650 Protein ID WP_114866913.1
Coordinates 1993988..1994317 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag K6972_RS09655 Protein ID WP_105249269.1
Coordinates 1994307..1994594 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6972_RS09635 (K6972_09635) 1989940..1991670 - 1731 WP_164503937.1 hypothetical protein -
K6972_RS09640 (K6972_09640) 1991878..1992750 - 873 WP_222759424.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
K6972_RS09645 (K6972_09645) 1992774..1993928 - 1155 WP_114866912.1 MBL fold metallo-hydrolase -
K6972_RS09650 (K6972_09650) 1993988..1994317 - 330 WP_114866913.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6972_RS09655 (K6972_09655) 1994307..1994594 - 288 WP_105249269.1 toxin-antitoxin system antitoxin subunit Antitoxin
K6972_RS09660 (K6972_09660) 1994692..1995060 - 369 WP_024391609.1 hypothetical protein -
K6972_RS09665 (K6972_09665) 1995053..1995643 - 591 WP_164503938.1 ribonuclease M5 -
K6972_RS09670 (K6972_09670) 1995606..1996388 - 783 WP_114867041.1 TatD family hydrolase -
K6972_RS09675 (K6972_09675) 1996473..1996610 - 138 WP_002939016.1 50S ribosomal protein L34 -
K6972_RS09680 (K6972_09680) 1996778..1997773 - 996 WP_013730624.1 RNA-binding cell elongation regulator Jag/EloR -
K6972_RS09685 (K6972_09685) 1997793..1998605 - 813 WP_114866914.1 YidC/Oxa1 family membrane protein insertase -
K6972_RS09690 (K6972_09690) 1998589..1998948 - 360 WP_004194560.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-95)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12580.55 Da        Isoelectric Point: 7.1991

>T214305 WP_114866913.1 NZ_CP082203:c1994317-1993988 [Streptococcus suis]
MEFESYSVMLAPAVEKELAAIYAYFSEQFSEEIAKRRIGMIVEALESLQIFPERGFNADNRFGKQVDPPHLTRGYVIGKD
YIVLYRVVKNEVRVGHLFATKSDYVKLLK

Download         Length: 330 bp

>T214305 NZ_CP110036:c52184-52011 [Enterococcus faecalis]
ATTTCTCTGAAAAATACGAATAAAAATATCGTTTACTGTACAACATATGAAACAATTCAGACGATCCTAGGGTTTGGTAT
GTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAAATAACCGTCTACTTTGACCAGT
ACGGTTATTTTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10906.50 Da        Isoelectric Point: 4.4616

>AT214305 WP_105249269.1 NZ_CP082203:c1994594-1994307 [Streptococcus suis]
MLTIKKDAQVNFKTDSRLLEKAKEVFAMNQLDLTAGFNLFLQNIAVKNELPILTEEELEREELFLQLQKEIQENQQAIEA
GHGISLESVKEKYGI

Download         Length: 288 bp

>AT214305 NZ_CP110036:51909-52111 [Enterococcus faecalis]
GTTTTTTTAGGTAATTGTGCTATAATAGCAATGAAAAGAGAGATATGCGCCAACATACCTCTCTGATGTAGAGCCGTTTA
AGACGGTGACCTTTTTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTTCTTGTCATTTTTAAGC
AATTTCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References