214303

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 694761..695247 Replicon chromosome
Accession NZ_CP082203
Organism Streptococcus suis strain NJ3

Toxin (Protein)


Gene name relE Uniprot ID D5AGV2
Locus tag K6972_RS03610 Protein ID WP_011922754.1
Coordinates 694978..695247 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AGV1
Locus tag K6972_RS03605 Protein ID WP_002938604.1
Coordinates 694761..694988 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6972_RS03580 (K6972_03580) 690125..690670 - 546 WP_002941732.1 NADPH-dependent FMN reductase -
K6972_RS03585 (K6972_03585) 690733..691182 - 450 WP_009909619.1 MarR family transcriptional regulator -
K6972_RS03590 (K6972_03590) 691396..691893 + 498 WP_105134088.1 DUF5590 domain-containing protein -
K6972_RS03595 (K6972_03595) 691890..693071 + 1182 WP_222812856.1 pyridoxal phosphate-dependent aminotransferase -
K6972_RS03600 (K6972_03600) 693086..694432 + 1347 WP_002941729.1 asparagine--tRNA ligase -
K6972_RS03605 (K6972_03605) 694761..694988 + 228 WP_002938604.1 DUF6290 family protein Antitoxin
K6972_RS03610 (K6972_03610) 694978..695247 + 270 WP_011922754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6972_RS03615 (K6972_03615) 695362..696681 + 1320 WP_222812857.1 MATE family efflux transporter -
K6972_RS03620 (K6972_03620) 696865..697242 + 378 WP_029171852.1 RidA family protein -
K6972_RS03625 (K6972_03625) 697264..698151 + 888 WP_024412169.1 RNase adapter RapZ -
K6972_RS03630 (K6972_03630) 698148..699122 + 975 WP_024400159.1 YvcK family protein -
K6972_RS03635 (K6972_03635) 699119..700036 + 918 WP_222812858.1 DNA-binding protein WhiA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10437.49 Da        Isoelectric Point: 10.3916

>T214303 WP_011922754.1 NZ_CP082203:694978-695247 [Streptococcus suis]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK

Download         Length: 270 bp

>T214303 NZ_CP110036:c51812-51669 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGAAATCCTAGAGGCTGTAAAAGAAAACAATAAAAAATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8450.51 Da        Isoelectric Point: 4.1589

>AT214303 WP_002938604.1 NZ_CP082203:694761-694988 [Streptococcus suis]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Download         Length: 228 bp

>AT214303 NZ_CP110036:c51525-51476 [Enterococcus faecalis]
AATAAAAATGCCCGAGCCTTAGAAAAATAAGAGGCTCGGGCATTTTTATT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126UKS2

Antitoxin

Source ID Structure
AlphaFold DB A0A140EXF0

References