Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sezT-pezT/zeta-couple_hipB
Location 282351..283609 Replicon chromosome
Accession NZ_CP082203
Organism Streptococcus suis strain NJ3

Toxin (Protein)


Gene name sezT Uniprot ID -
Locus tag K6972_RS01565 Protein ID WP_222759705.1
Coordinates 282827..283609 (+) Length 261 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID -
Locus tag K6972_RS01560 Protein ID WP_136628421.1
Coordinates 282351..282827 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6972_RS01540 (K6972_01540) 278098..278943 + 846 WP_024384741.1 MIP/aquaporin family protein -
K6972_RS01545 (K6972_01545) 279071..280603 + 1533 WP_222812697.1 DUF853 family protein -
K6972_RS01550 (K6972_01550) 280716..281330 + 615 WP_044751282.1 CoA pyrophosphatase -
K6972_RS01555 (K6972_01555) 281374..282042 - 669 WP_136628420.1 aquaporin -
K6972_RS01560 (K6972_01560) 282351..282827 + 477 WP_136628421.1 type II toxin-antitoxin system antitoxin PezA Antitoxin
K6972_RS01565 (K6972_01565) 282827..283609 + 783 WP_222759705.1 type II toxin-antitoxin system toxin PezT Toxin
K6972_RS10525 283613..284539 + 927 WP_261984182.1 hypothetical protein -
K6972_RS01575 (K6972_01575) 285059..285826 + 768 WP_222812698.1 DeoR/GlpR family DNA-binding transcription regulator -
K6972_RS01580 (K6972_01580) 286031..286453 + 423 WP_222812699.1 galactose-6-phosphate isomerase subunit LacA -
K6972_RS01585 (K6972_01585) 286480..286995 + 516 WP_018031055.1 galactose-6-phosphate isomerase subunit LacB -
K6972_RS01590 (K6972_01590) 287005..287937 + 933 WP_222812700.1 tagatose-6-phosphate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(28-214)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 261 a.a.        Molecular weight: 29713.63 Da        Isoelectric Point: 6.5044

>T214302 WP_222759705.1 NZ_CP082203:282827-283609 [Streptococcus suis]
MRLEEFSEADFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEHLVDELSTQGYHLLIEGTLRTTQVPRQTAQFLASKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPNQARATPKEHHDGIVENLVDNLSELEREQLFDCIQIYQRDRTCIYDSKTYEGSAAEVLQEYLFGKWSKVEEEML
KMGQERLRELNKGSNKGMER

Download         Length: 783 bp

>T214302 NZ_CP110020:2786630-2786725 [Enterococcus faecalis]
ATGTACGAGATTGTCACAAAAATTCTTGTGCCGATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGTTGGAAAA
ACAGAACGAGGAATAA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18245.62 Da        Isoelectric Point: 4.3241

>AT214302 WP_136628421.1 NZ_CP082203:282351-282827 [Streptococcus suis]
MIGDNIKSLRQTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYQLTLKVE
VIKERGAAILSQLYRYQDSQDIAFDDESNPWILMSDDLAELINTKIYLVDTFDEIERYNGYLDGIERMLDMVHHRVVA

Download         Length: 477 bp

>AT214302 NZ_CP110020:c2786824-2786760 [Enterococcus faecalis]
CTTGTGACAAAGTCGTGCATGGATGCACTAAAAAGACACCCTATTGTGGTAGGGTGTCTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References