Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 2096849..2097455 Replicon chromosome
Accession NZ_CP082202
Organism Streptococcus suis strain SS389

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag K6976_RS10025 Protein ID WP_114866913.1
Coordinates 2096849..2097178 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag K6976_RS10030 Protein ID WP_105249269.1
Coordinates 2097168..2097455 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6976_RS10010 (K6976_10010) 2092802..2094520 - 1719 WP_261987985.1 hypothetical protein -
K6976_RS10015 (K6976_10015) 2094740..2095612 - 873 WP_222759424.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
K6976_RS10020 (K6976_10020) 2095719..2096789 - 1071 WP_222759425.1 MBL fold metallo-hydrolase -
K6976_RS10025 (K6976_10025) 2096849..2097178 - 330 WP_114866913.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6976_RS10030 (K6976_10030) 2097168..2097455 - 288 WP_105249269.1 toxin-antitoxin system antitoxin subunit Antitoxin
K6976_RS10035 (K6976_10035) 2097553..2097921 - 369 WP_024391609.1 hypothetical protein -
K6976_RS10040 (K6976_10040) 2097914..2098504 - 591 WP_164503938.1 ribonuclease M5 -
K6976_RS10045 (K6976_10045) 2098467..2099249 - 783 WP_114867041.1 TatD family hydrolase -
K6976_RS10050 (K6976_10050) 2099334..2099471 - 138 WP_002939016.1 50S ribosomal protein L34 -
K6976_RS10055 (K6976_10055) 2099639..2100634 - 996 WP_013730624.1 RNA-binding cell elongation regulator Jag/EloR -
K6976_RS10060 (K6976_10060) 2100654..2101454 - 801 WP_222759427.1 YidC/Oxa1 family membrane protein insertase -
K6976_RS10065 (K6976_10065) 2101438..2101797 - 360 WP_004194560.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-95)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12580.55 Da        Isoelectric Point: 7.1991

>T214301 WP_114866913.1 NZ_CP082202:c2097178-2096849 [Streptococcus suis]
MEFESYSVMLAPAVEKELAAIYAYFSEQFSEEIAKRRIGMIVEALESLQIFPERGFNADNRFGKQVDPPHLTRGYVIGKD
YIVLYRVVKNEVRVGHLFATKSDYVKLLK

Download         Length: 330 bp

>T214301 NZ_CP110020:c2494439-2494323 [Enterococcus faecalis]
ATGTTTTTGTCCGTTGAAGCAGCGCTAGGACTGATGATTGGTTTTGCAACGCTTGTTGTGACCATTATCTTCGGTATCTT
AGCGCTTGTCTTAGACAACAAAAATAACCGTTCATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10906.50 Da        Isoelectric Point: 4.4616

>AT214301 WP_105249269.1 NZ_CP082202:c2097455-2097168 [Streptococcus suis]
MLTIKKDAQVNFKTDSRLLEKAKEVFAMNQLDLTAGFNLFLQNIAVKNELPILTEEELEREELFLQLQKEIQENQQAIEA
GHGISLESVKEKYGI

Download         Length: 288 bp

>AT214301 NZ_CP110020:2494207-2494412 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACCAGTTATAAGAACTGGTGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGCGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References