Detailed information of TA system TA214300

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1080452..1080947
• Replicon: chromosome
• Accession: NZ_CP082202
• Organism: Streptococcus suis strain SS389

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: K6976_RS05390
• Protein ID: WP_222760131.1
• Coordinates: 1080681..1080947 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: K6976_RS05385
• Protein ID: WP_208572645.1
• Coordinates: 1080452..1080691 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K6976_RS05360 (K6976_05360)	1075781..1076947	+	1167	WP_222760127.1	ATP-grasp domain-containing protein	-
K6976_RS05365 (K6976_05365)	1077087..1077227	+	141	WP_222760128.1	hypothetical protein	-
K6976_RS05370 (K6976_05370)	1077240..1077629	+	390	WP_222760129.1	NisI/SpaI family lantibiotic immunity lipoprotein	-
K6976_RS05375 (K6976_05375)	1077638..1078390	+	753	WP_172078915.1	ABC transporter ATP-binding protein	-
K6976_RS05380 (K6976_05380)	1078391..1080361	+	1971	WP_222760130.1	ABC transporter permease	-
K6976_RS05385 (K6976_05385)	1080452..1080691	+	240	WP_208572645.1	DUF6290 family protein	Antitoxin
K6976_RS05390 (K6976_05390)	1080681..1080947	+	267	WP_222760131.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K6976_RS05395 (K6976_05395)	1080986..1081654	+	669	WP_161943716.1	response regulator transcription factor	-
K6976_RS05400 (K6976_05400)	1081651..1082592	+	942	WP_222760132.1	sensor histidine kinase	-
K6976_RS05405 (K6976_05405)	1082668..1084176	+	1509	WP_222760133.1	phosphomannomutase/phosphoglucomutase	-
K6976_RS05410 (K6976_05410)	1084240..1085310	-	1071	WP_074391129.1	tyrosine recombinase XerS	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Protein of unknown function DUF6290 (1-75)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10236.94 Da
• Isoelectric Point: 10.4518

>T214300 WP_222760131.1 NZ_CP082202:1080681-1080947 [Streptococcus suis]
MSYKVILSAKAQKQIRKMDKTAASLILRYLYKHIDGCDNPRQYGKALTANRSGQWRYRIGNYRVIVSIEDDKLIVTALEV
GQRKEVYK

Nucleotide

• Length: 267 bp

>T214300 NZ_CP110020:c610956-610303 [Enterococcus faecalis]
TTGATTGGACTGTTGTTGGTGGATTTTATTAGTAAAGAACTCTATTTTGAAGCATTTAATTTTTCGAACGAATTAATAAA
AGAAGTATCTTACTACTCTTCCAAAAATATTGAACAAGTTAAATGCTTTGATATTGAAAAATATGTAAAAGAAGTTGAAG
ATGTTGAATTTGTTGAATACACGTTTCAAAAACAACTTAAAAGACGGATGCTTGGTTCAATCTCTAAAGTAGACGATGAA
GTCATTATAACAACAAACAAAGAATTAATGTTAGAACGAAAAAATTTCACTAAAATGCATGAGGTTATGCATTACTACAT
AGATATACCTAAAATTAATAATGCAACTCATACTTTTTCTGATATTCTTTTGAAAAATGGTTACTTGATGGAAGATTTTC
CAAAAGAATATCGTGCTAATGTCGGTGCTAGTATGTTAATGGCAAATGATCAAGCATTGTTTTACGCATTAAAAAAATTT
TATTCATTCGAAGAAATTGCACAATACTTTTTTATGAGCAAATCTGCATTAAGAAATAGACTCATCGAGCATCTTATGTA
TGTAAATAATTGTACTTTTGCACACGCTAATACACTTTTTAACAATTATTACTTTCATAAAGAAACTGATATCTACAGAT
TTATTTTCAATTAG

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8907.14 Da
• Isoelectric Point: 3.7832

>AT214300 WP_208572645.1 NZ_CP082202:1080452-1080691 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIAWVEYQEDLANGIEPITLEQMAEELGIEL

Nucleotide

• Length: 240 bp

>AT214300 NZ_CP110020:c611339-610953 [Enterococcus faecalis]
GTGACTATTATTAAAACAAATGAACGTTTGAAACAACTACGTGAAAATAAAGAATTAACTCAAAAAGAATTAGCTGATTT
ACTGCACATGGATAGAAGTGTTTATAATAAAATTGAATCAGGTGCTCGTCCCATTCGTGATAACGAACTAATTCAATTTG
CGGATTTCTATAATGTATCAACAGACTACCTTACAAATAGAACTAACAATCCCATTCCCCCTGAAGAAAAAACAAATGTG
GGACAAAATATCATCTCACATTTTCGTCTTAATACTTCTGATATGGACATAGAAGATATAGAAGAATTAGAAGAAGAATT
AATCGACTTTCAAGATTTTCTTATAAAAAAAGCAAAAGAAAAAAAGGAACGTAACAAAAAAGATTGA