Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 656093..656766 Replicon chromosome
Accession NZ_CP082202
Organism Streptococcus suis strain SS389

Toxin (Protein)


Gene name hicA Uniprot ID A0A139MTI1
Locus tag K6976_RS03375 Protein ID WP_024402467.1
Coordinates 656584..656766 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A123TH46
Locus tag K6976_RS03370 Protein ID WP_023371005.1
Coordinates 656093..656545 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6976_RS03360 (K6976_03360) 652071..655136 + 3066 WP_222760162.1 type I restriction endonuclease subunit R -
K6976_RS03365 (K6976_03365) 655772..655981 - 210 WP_024407482.1 hypothetical protein -
K6976_RS03370 (K6976_03370) 656093..656545 - 453 WP_023371005.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
K6976_RS03375 (K6976_03375) 656584..656766 - 183 WP_024402467.1 type II toxin-antitoxin system HicA family toxin Toxin
K6976_RS03380 (K6976_03380) 656951..657337 - 387 WP_024407483.1 sigma-70 family RNA polymerase sigma factor -
K6976_RS03385 (K6976_03385) 657700..658200 - 501 WP_024407484.1 hypothetical protein -
K6976_RS03390 (K6976_03390) 658270..658710 - 441 WP_024407485.1 hypothetical protein -
K6976_RS03395 (K6976_03395) 659039..660493 - 1455 WP_261988004.1 DNA primase family protein -
K6976_RS03400 (K6976_03400) 660553..661416 - 864 WP_024407487.1 primase alpha helix C-terminal domain-containing protein -
K6976_RS10890 661397..661684 - 288 WP_024407488.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 652071..672930 20859


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-82)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6665.93 Da        Isoelectric Point: 10.8207

>T214299 WP_024402467.1 NZ_CP082202:c656766-656584 [Streptococcus suis]
MPMTQKEMVKLLTAHGWIKTKGGKGSHVKLEKAGERPITIPHGEINKYTERGIKKQAGLL

Download         Length: 183 bp

>T214299 NZ_CP110020:383140-383244 [Enterococcus faecalis]
TTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGGTATGTTTACCATTGCTTTGATTGTGCTGATTGTGAAATT
GCTTAAAAATGACAATAAAAAATAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16685.68 Da        Isoelectric Point: 4.0098

>AT214299 WP_023371005.1 NZ_CP082202:c656545-656093 [Streptococcus suis]
MLVTYPALFYYDDTDGANAPYFVTFPDFEHSATQGEDMADAMAMASDWLGIHLADYIENGRDIPTPTPINALSLADNNPF
RDDKDIELVYDPSKSFVSMVMVDVAEYLGSQEPVKKTLTIPRWADTLGRELGLNFSQTLTDAIADKKIHA

Download         Length: 453 bp

>AT214299 NZ_CP110020:c383364-383177 [Enterococcus faecalis]
TGTGCTATAATAAAAATGAAAAGAGAGACATGCTTCAACATACCTCTCTGATGCAGAGCCGTTTAAGACGGTGACCATGT
TAATTATTTAAAAATAACCGTGCTTGGTCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAAGCAATTTCACAATCAGC
ACAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A139MTI1

Antitoxin

Source ID Structure
AlphaFold DB A0A123TH46

References