Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sezT-pezT/zeta-couple_hipB
Location 250626..251884 Replicon chromosome
Accession NZ_CP082202
Organism Streptococcus suis strain SS389

Toxin (Protein)


Gene name sezT Uniprot ID -
Locus tag K6976_RS01335 Protein ID WP_222759705.1
Coordinates 251102..251884 (+) Length 261 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID -
Locus tag K6976_RS01330 Protein ID WP_136628421.1
Coordinates 250626..251102 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6976_RS01310 (K6976_01310) 246372..247217 + 846 WP_222759701.1 MIP/aquaporin family protein -
K6976_RS01315 (K6976_01315) 247346..248878 + 1533 WP_136628419.1 DUF853 family protein -
K6976_RS01320 (K6976_01320) 248991..249605 + 615 WP_044751282.1 CoA pyrophosphatase -
K6976_RS01325 (K6976_01325) 249649..250317 - 669 WP_222759703.1 aquaporin -
K6976_RS01330 (K6976_01330) 250626..251102 + 477 WP_136628421.1 type II toxin-antitoxin system antitoxin PezA Antitoxin
K6976_RS01335 (K6976_01335) 251102..251884 + 783 WP_222759705.1 type II toxin-antitoxin system toxin PezT Toxin
K6976_RS01340 (K6976_01340) 251888..252964 + 1077 WP_222759707.1 SIR2 family protein -
K6976_RS01345 (K6976_01345) 252976..254694 + 1719 WP_105136645.1 ATP-binding protein -
K6976_RS01350 (K6976_01350) 255214..255981 + 768 WP_222759709.1 DeoR/GlpR family DNA-binding transcription regulator -
K6976_RS01355 (K6976_01355) 256186..256608 + 423 WP_024384734.1 galactose-6-phosphate isomerase subunit LacA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(28-214)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 261 a.a.        Molecular weight: 29713.63 Da        Isoelectric Point: 6.5044

>T214298 WP_222759705.1 NZ_CP082202:251102-251884 [Streptococcus suis]
MRLEEFSEADFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEHLVDELSTQGYHLLIEGTLRTTQVPRQTAQFLASKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPNQARATPKEHHDGIVENLVDNLSELEREQLFDCIQIYQRDRTCIYDSKTYEGSAAEVLQEYLFGKWSKVEEEML
KMGQERLRELNKGSNKGMER

Download         Length: 783 bp

>T214298 NZ_CP110019:c2495815-2495711 [Enterococcus faecalis]
TTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGGTATGTTTACCATTGCTTTGATTGTGCTGATTGTGAAATT
GCTTAAAAATGACAATAAAAAATAA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18245.62 Da        Isoelectric Point: 4.3241

>AT214298 WP_136628421.1 NZ_CP082202:250626-251102 [Streptococcus suis]
MIGDNIKSLRQTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYQLTLKVE
VIKERGAAILSQLYRYQDSQDIAFDDESNPWILMSDDLAELINTKIYLVDTFDEIERYNGYLDGIERMLDMVHHRVVA

Download         Length: 477 bp

>AT214298 NZ_CP110019:2495591-2495778 [Enterococcus faecalis]
TGTGCTATAATAAAAATGAAAAGAGAGACATGCTTCAACATACCTCTCTGATGCAGAGCCGTTTAAGACGGTGACCATGT
TAATTATTTAAAAATAACCGTGCTTGGTCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAAGCAATTTCACAATCAGC
ACAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References