Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 915314..915806 Replicon chromosome
Accession NZ_CP082201
Organism Streptococcus suis strain Transconjugant cAKJ18

Toxin (Protein)


Gene name relE Uniprot ID D5AHJ6
Locus tag K6967_RS04510 Protein ID WP_011922404.1
Coordinates 915314..915571 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AHJ7
Locus tag K6967_RS04515 Protein ID WP_012775104.1
Coordinates 915555..915806 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6967_RS04490 (K6967_04490) 910948..912018 + 1071 WP_012775436.1 tyrosine recombinase XerS -
K6967_RS04495 (K6967_04495) 912088..913596 - 1509 WP_011922400.1 phosphomannomutase/phosphoglucomutase -
K6967_RS04500 (K6967_04500) 913672..914613 - 942 WP_012775102.1 sensor histidine kinase -
K6967_RS04505 (K6967_04505) 914610..915275 - 666 WP_012775103.1 response regulator transcription factor -
K6967_RS04510 (K6967_04510) 915314..915571 - 258 WP_011922404.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6967_RS04515 (K6967_04515) 915555..915806 - 252 WP_012775104.1 DUF6290 family protein Antitoxin
K6967_RS04520 (K6967_04520) 915898..917868 - 1971 WP_012775105.1 FtsX-like permease family protein -
K6967_RS04525 (K6967_04525) 917869..918621 - 753 WP_011922409.1 ABC transporter ATP-binding protein -
K6967_RS04530 (K6967_04530) 918757..919491 - 735 WP_011922410.1 ABC transporter permease -
K6967_RS04535 (K6967_04535) 919493..920239 - 747 WP_011922411.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-75)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9981.62 Da        Isoelectric Point: 10.8924

>T214294 WP_011922404.1 NZ_CP082201:c915571-915314 [Streptococcus suis]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI

Download         Length: 258 bp

>T214294 NZ_CP110018:4548427-4548777 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9325.59 Da        Isoelectric Point: 3.7666

>AT214294 WP_012775104.1 NZ_CP082201:c915806-915555 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIALSEYEADLAKGIEPISWEEMLEELGLTDE
DLL

Download         Length: 252 bp

>AT214294 NZ_CP110018:4548182-4548433 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8U747

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9GU89

References