Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 653037..653523 Replicon chromosome
Accession NZ_CP082201
Organism Streptococcus suis strain Transconjugant cAKJ18

Toxin (Protein)


Gene name relE Uniprot ID D5AGV2
Locus tag K6967_RS03270 Protein ID WP_011922754.1
Coordinates 653254..653523 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AGV1
Locus tag K6967_RS03265 Protein ID WP_002938604.1
Coordinates 653037..653264 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6967_RS03240 (K6967_03240) 648080..648529 - 450 WP_009909619.1 MarR family transcriptional regulator -
K6967_RS03245 (K6967_03245) 648823..649670 + 848 WP_087892711.1 IS630 family transposase -
K6967_RS03250 (K6967_03250) 649729..650226 + 498 WP_011922751.1 DUF5590 domain-containing protein -
K6967_RS03255 (K6967_03255) 650223..651404 + 1182 WP_011922154.1 pyridoxal phosphate-dependent aminotransferase -
K6967_RS03260 (K6967_03260) 651419..652765 + 1347 WP_011922752.1 asparagine--tRNA ligase -
K6967_RS03265 (K6967_03265) 653037..653264 + 228 WP_002938604.1 DUF6290 family protein Antitoxin
K6967_RS03270 (K6967_03270) 653254..653523 + 270 WP_011922754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6967_RS03275 (K6967_03275) 653929..655248 + 1320 WP_012775027.1 MATE family efflux transporter -
K6967_RS03280 (K6967_03280) 655299..655676 + 378 WP_002937263.1 RidA family protein -
K6967_RS03285 (K6967_03285) 655698..656585 + 888 WP_011922160.1 RNase adapter RapZ -
K6967_RS03290 (K6967_03290) 656582..657556 + 975 WP_002937257.1 YvcK family protein -
K6967_RS03295 (K6967_03295) 657553..658470 + 918 WP_002937252.1 DNA-binding protein WhiA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10437.49 Da        Isoelectric Point: 10.3916

>T214293 WP_011922754.1 NZ_CP082201:653254-653523 [Streptococcus suis]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK

Download         Length: 270 bp

>T214293 NZ_CP110018:4452643-4452816 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8450.51 Da        Isoelectric Point: 4.1589

>AT214293 WP_002938604.1 NZ_CP082201:653037-653264 [Streptococcus suis]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Download         Length: 228 bp

>AT214293 NZ_CP110018:4452319-4452615 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126UKS2

Antitoxin

Source ID Structure
AlphaFold DB A0A140EXF0

References