Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 914762..915254 Replicon chromosome
Accession NZ_CP082200
Organism Streptococcus suis strain Transconjugant cDY107

Toxin (Protein)


Gene name relE Uniprot ID D5AHJ6
Locus tag K6971_RS04505 Protein ID WP_011922404.1
Coordinates 914762..915019 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AHJ7
Locus tag K6971_RS04510 Protein ID WP_012775104.1
Coordinates 915003..915254 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6971_RS04485 (K6971_04485) 910396..911466 + 1071 WP_012775436.1 tyrosine recombinase XerS -
K6971_RS04490 (K6971_04490) 911536..913044 - 1509 WP_011922400.1 phosphomannomutase/phosphoglucomutase -
K6971_RS04495 (K6971_04495) 913120..914061 - 942 WP_012775102.1 sensor histidine kinase -
K6971_RS04500 (K6971_04500) 914058..914723 - 666 WP_012775103.1 response regulator transcription factor -
K6971_RS04505 (K6971_04505) 914762..915019 - 258 WP_011922404.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6971_RS04510 (K6971_04510) 915003..915254 - 252 WP_012775104.1 DUF6290 family protein Antitoxin
K6971_RS04515 (K6971_04515) 915346..917316 - 1971 WP_012775105.1 FtsX-like permease family protein -
K6971_RS04520 (K6971_04520) 917317..918069 - 753 WP_011922409.1 ABC transporter ATP-binding protein -
K6971_RS04525 (K6971_04525) 918205..918939 - 735 WP_011922410.1 ABC transporter permease -
K6971_RS04530 (K6971_04530) 918941..919687 - 747 WP_011922411.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-75)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9981.62 Da        Isoelectric Point: 10.8924

>T214289 WP_011922404.1 NZ_CP082200:c915019-914762 [Streptococcus suis]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI

Download         Length: 258 bp

>T214289 NZ_CP110018:c3265660-3265364 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9325.59 Da        Isoelectric Point: 3.7666

>AT214289 WP_012775104.1 NZ_CP082200:c915254-915003 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIALSEYEADLAKGIEPISWEEMLEELGLTDE
DLL

Download         Length: 252 bp

>AT214289 NZ_CP110018:c3265362-3264967 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8U747

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9GU89

References