Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 912882..913374 Replicon chromosome
Accession NZ_CP082199
Organism Streptococcus suis strain Transconjugant cFJSM5

Toxin (Protein)


Gene name relE Uniprot ID D5AHJ6
Locus tag K6970_RS04480 Protein ID WP_011922404.1
Coordinates 912882..913139 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AHJ7
Locus tag K6970_RS04485 Protein ID WP_012775104.1
Coordinates 913123..913374 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6970_RS04460 (K6970_04460) 908516..909586 + 1071 WP_012775436.1 tyrosine recombinase XerS -
K6970_RS04465 (K6970_04465) 909656..911164 - 1509 WP_011922400.1 phosphomannomutase/phosphoglucomutase -
K6970_RS04470 (K6970_04470) 911240..912181 - 942 WP_012775102.1 sensor histidine kinase -
K6970_RS04475 (K6970_04475) 912178..912843 - 666 WP_012775103.1 response regulator transcription factor -
K6970_RS04480 (K6970_04480) 912882..913139 - 258 WP_011922404.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6970_RS04485 (K6970_04485) 913123..913374 - 252 WP_012775104.1 DUF6290 family protein Antitoxin
K6970_RS04490 (K6970_04490) 913466..915436 - 1971 WP_012775105.1 FtsX-like permease family protein -
K6970_RS04495 (K6970_04495) 915437..916189 - 753 WP_011922409.1 ABC transporter ATP-binding protein -
K6970_RS04500 (K6970_04500) 916325..917059 - 735 WP_011922410.1 ABC transporter permease -
K6970_RS04505 (K6970_04505) 917061..917807 - 747 WP_011922411.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-75)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9981.62 Da        Isoelectric Point: 10.8924

>T214284 WP_011922404.1 NZ_CP082199:c913139-912882 [Streptococcus suis]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI

Download         Length: 258 bp

>T214284 NZ_CP110018:c2178745-2178494 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9325.59 Da        Isoelectric Point: 3.7666

>AT214284 WP_012775104.1 NZ_CP082199:c913374-913123 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIALSEYEADLAKGIEPISWEEMLEELGLTDE
DLL

Download         Length: 252 bp

>AT214284 NZ_CP110018:c2178497-2178243 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8U747

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9GU89

References