Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 650640..651126 Replicon chromosome
Accession NZ_CP082199
Organism Streptococcus suis strain Transconjugant cFJSM5

Toxin (Protein)


Gene name relE Uniprot ID D5AGV2
Locus tag K6970_RS03245 Protein ID WP_011922754.1
Coordinates 650857..651126 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AGV1
Locus tag K6970_RS03240 Protein ID WP_002938604.1
Coordinates 650640..650867 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6970_RS03215 (K6970_03215) 645683..646132 - 450 WP_009909619.1 MarR family transcriptional regulator -
K6970_RS03220 (K6970_03220) 646426..647273 + 848 WP_087892711.1 IS630 family transposase -
K6970_RS03225 (K6970_03225) 647332..647829 + 498 WP_011922751.1 DUF5590 domain-containing protein -
K6970_RS03230 (K6970_03230) 647826..649007 + 1182 WP_011922154.1 pyridoxal phosphate-dependent aminotransferase -
K6970_RS03235 (K6970_03235) 649022..650368 + 1347 WP_011922752.1 asparagine--tRNA ligase -
K6970_RS03240 (K6970_03240) 650640..650867 + 228 WP_002938604.1 DUF6290 family protein Antitoxin
K6970_RS03245 (K6970_03245) 650857..651126 + 270 WP_011922754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6970_RS03250 (K6970_03250) 651532..652851 + 1320 WP_012775027.1 MATE family efflux transporter -
K6970_RS03255 (K6970_03255) 652902..653279 + 378 WP_002937263.1 RidA family protein -
K6970_RS03260 (K6970_03260) 653301..654188 + 888 WP_011922160.1 RNase adapter RapZ -
K6970_RS03265 (K6970_03265) 654185..655159 + 975 WP_002937257.1 YvcK family protein -
K6970_RS03270 (K6970_03270) 655156..656073 + 918 WP_002937252.1 DNA-binding protein WhiA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10437.49 Da        Isoelectric Point: 10.3916

>T214283 WP_011922754.1 NZ_CP082199:650857-651126 [Streptococcus suis]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK

Download         Length: 270 bp

>T214283 NZ_CP110018:c2178497-2178243 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8450.51 Da        Isoelectric Point: 4.1589

>AT214283 WP_002938604.1 NZ_CP082199:650640-650867 [Streptococcus suis]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Download         Length: 228 bp

>AT214283 NZ_CP110018:c2178745-2178494 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126UKS2

Antitoxin

Source ID Structure
AlphaFold DB A0A140EXF0

References