Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 896414..896906 Replicon chromosome
Accession NZ_CP082197
Organism Streptococcus suis strain Transconjugant cSS389

Toxin (Protein)


Gene name relE Uniprot ID D5AHJ6
Locus tag K6975_RS04440 Protein ID WP_011922404.1
Coordinates 896649..896906 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AHJ7
Locus tag K6975_RS04435 Protein ID WP_012775104.1
Coordinates 896414..896665 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6975_RS04415 (K6975_04415) 891981..892727 + 747 WP_011922411.1 ABC transporter permease -
K6975_RS04420 (K6975_04420) 892729..893463 + 735 WP_011922410.1 ABC transporter permease -
K6975_RS04425 (K6975_04425) 893599..894351 + 753 WP_011922409.1 ABC transporter ATP-binding protein -
K6975_RS04430 (K6975_04430) 894352..896322 + 1971 WP_012775105.1 FtsX-like permease family protein -
K6975_RS04435 (K6975_04435) 896414..896665 + 252 WP_012775104.1 DUF6290 family protein Antitoxin
K6975_RS04440 (K6975_04440) 896649..896906 + 258 WP_011922404.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6975_RS04445 (K6975_04445) 896945..897610 + 666 WP_012775103.1 response regulator transcription factor -
K6975_RS04450 (K6975_04450) 897607..898548 + 942 WP_012775102.1 sensor histidine kinase -
K6975_RS04455 (K6975_04455) 898624..900132 + 1509 WP_011922400.1 phosphomannomutase/phosphoglucomutase -
K6975_RS04460 (K6975_04460) 900202..901272 - 1071 WP_012775436.1 tyrosine recombinase XerS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-75)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9981.62 Da        Isoelectric Point: 10.8924

>T214273 WP_011922404.1 NZ_CP082197:896649-896906 [Streptococcus suis]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI

Download         Length: 258 bp

>T214273 NZ_CP110018:c418863-418645 [Escherichia coli]
ATGTCCGAAAAATTTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9325.59 Da        Isoelectric Point: 3.7666

>AT214273 WP_012775104.1 NZ_CP082197:896414-896665 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIALSEYEADLAKGIEPISWEEMLEELGLTDE
DLL

Download         Length: 252 bp

>AT214273 NZ_CP110018:c419263-418889 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8U747

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9GU89

References