Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1022742..1023520 Replicon chromosome
Accession NZ_CP082178
Organism Xanthomonas fragariae strain SHQP01

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag K4A87_RS04795 Protein ID WP_208589526.1
Coordinates 1022742..1023233 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID G0CD67
Locus tag K4A87_RS04800 Protein ID WP_014508712.1
Coordinates 1023230..1023520 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K4A87_RS04775 (K4A87_04735) 1018526..1019431 + 906 WP_208589518.1 30S ribosomal protein S6--L-glutamate ligase -
K4A87_RS04780 1019654..1020097 + 444 Protein_891 hypothetical protein -
K4A87_RS04785 (K4A87_04740) 1020123..1020800 + 678 WP_003490678.1 response regulator transcription factor -
K4A87_RS04790 (K4A87_04745) 1021259..1022593 + 1335 WP_208589524.1 HAMP domain-containing sensor histidine kinase -
K4A87_RS04795 (K4A87_04750) 1022742..1023233 - 492 WP_208589526.1 GNAT family N-acetyltransferase Toxin
K4A87_RS04800 (K4A87_04755) 1023230..1023520 - 291 WP_014508712.1 DUF1778 domain-containing protein Antitoxin
K4A87_RS04805 (K4A87_04760) 1023596..1024001 - 406 Protein_896 type I toxin-antitoxin system SymE family toxin -
K4A87_RS04810 (K4A87_04765) 1024374..1024706 - 333 WP_208589528.1 hypothetical protein -
K4A87_RS04815 (K4A87_04770) 1025139..1026188 - 1050 Protein_898 RHS repeat-associated core domain-containing protein -
K4A87_RS04820 (K4A87_04775) 1026202..1026441 - 240 WP_208589530.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(26-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17514.19 Da        Isoelectric Point: 8.9888

>T214266 WP_208589526.1 NZ_CP082178:c1023233-1022742 [Xanthomonas fragariae]
MTVSAPEPLTAHHRVEPFASGLESLDHWLKRRALKNQATGASRTVVACADDRVVAYYALASSAVAVDATPGRFRRNMPDP
IPVVVLGRLAVDQSLHGRGFGRALVQDAGKRILHAADTIGIRGLLVHALSADAKAFYERIGFEPSPLDPMVLVVTLEDLK
ASL

Download         Length: 492 bp

>T214266 NZ_CP110017:c3797200-3797093 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10648.20 Da        Isoelectric Point: 10.5480

>AT214266 WP_014508712.1 NZ_CP082178:c1023520-1023230 [Xanthomonas fragariae]
MSTPNTTPGKRETLNLRIKPEERSLIDRAAKARGKNRTDFMLDAARSAAEEALLDQTLIAASPDAYAAFLARLDMPPQPN
ARLRKTMQTPAPWEKA

Download         Length: 291 bp

>AT214266 NZ_CP110017:3797248-3797314 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3E1LB51

References