Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 10260833..10261494 Replicon chromosome
Accession NZ_CP082164
Organism Bradyrhizobium sp. 186

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag IVB18_RS49035 Protein ID WP_247987189.1
Coordinates 10261087..10261494 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag IVB18_RS49030 Protein ID WP_247987188.1
Coordinates 10260833..10261087 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IVB18_RS49010 (IVB18_48390) 10256349..10256828 - 480 WP_247987184.1 DUF1579 family protein -
IVB18_RS49015 (IVB18_48395) 10256833..10258029 - 1197 WP_247987185.1 ADP-forming succinate--CoA ligase subunit beta -
IVB18_RS49020 (IVB18_48400) 10258232..10259200 - 969 WP_247987186.1 malate dehydrogenase -
IVB18_RS49025 (IVB18_48405) 10259450..10260634 - 1185 WP_247987187.1 cell division protein ZapE -
IVB18_RS49030 (IVB18_48410) 10260833..10261087 + 255 WP_247987188.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
IVB18_RS49035 (IVB18_48415) 10261087..10261494 + 408 WP_247987189.1 type II toxin-antitoxin system VapC family toxin Toxin
IVB18_RS49040 (IVB18_48420) 10261526..10262062 - 537 WP_247987190.1 RNA 2',3'-cyclic phosphodiesterase -
IVB18_RS49045 (IVB18_48425) 10262237..10262881 - 645 WP_247987191.1 arylesterase -
IVB18_RS49050 (IVB18_48430) 10262937..10263659 + 723 WP_247987192.1 ABC transporter ATP-binding protein -
IVB18_RS49055 (IVB18_48435) 10263656..10266226 + 2571 WP_247987193.1 FtsX-like permease family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14549.65 Da        Isoelectric Point: 4.9264

>T214264 WP_247987189.1 NZ_CP082164:10261087-10261494 [Bradyrhizobium sp. 186]
MVIDTSAIVAIALNEPDASRMEIQIADDPVRLISAATVLEAAMVLETRMGDAGGREFDLWLLKIGAEIVAVDAEQTDAAR
RAWRRYGKGRHAAALNYGDCFSYALAVTRSEPLLFKGGGDFAKTDISRPGVAPLR

Download         Length: 408 bp

>T214264 NZ_CP110017:c3331567-3331253 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9715.02 Da        Isoelectric Point: 6.2336

>AT214264 WP_247987188.1 NZ_CP082164:10260833-10261087 [Bradyrhizobium sp. 186]
MALSIKDHETELLARNLAKLTGENITTATKRAIEERLHRLGSQSRKTALLEDMAEIRRRWSEMPVVDDRTPEEILGYDEH
GFPR

Download         Length: 255 bp

>AT214264 NZ_CP110017:c3331256-3330840 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References