Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 9901535..9902169 Replicon chromosome
Accession NZ_CP082164
Organism Bradyrhizobium sp. 186

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag IVB18_RS47335 Protein ID WP_247986891.1
Coordinates 9901535..9901939 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag IVB18_RS47340 Protein ID WP_247986892.1
Coordinates 9901936..9902169 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IVB18_RS47310 (IVB18_46715) 9896868..9897725 + 858 WP_247986886.1 branched-chain amino acid ABC transporter permease -
IVB18_RS47315 (IVB18_46720) 9897729..9898949 + 1221 WP_247986887.1 substrate-binding protein -
IVB18_RS47320 (IVB18_46725) 9898956..9900074 + 1119 WP_247986888.1 branched-chain amino acid ABC transporter permease -
IVB18_RS47325 (IVB18_46730) 9900061..9900795 + 735 WP_247986889.1 ABC transporter ATP-binding protein -
IVB18_RS47330 (IVB18_46735) 9900788..9901483 + 696 WP_247986890.1 ABC transporter ATP-binding protein -
IVB18_RS47335 (IVB18_46740) 9901535..9901939 - 405 WP_247986891.1 PIN domain-containing protein Toxin
IVB18_RS47340 (IVB18_46745) 9901936..9902169 - 234 WP_247986892.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
IVB18_RS47345 (IVB18_46750) 9902320..9903855 - 1536 WP_247986893.1 murein L,D-transpeptidase family protein -
IVB18_RS47350 (IVB18_46755) 9904271..9905233 - 963 WP_247986894.1 acetyl-CoA carboxylase carboxyltransferase subunit alpha -
IVB18_RS47355 (IVB18_46760) 9905517..9906488 - 972 WP_247986895.1 site-specific tyrosine recombinase XerD -
IVB18_RS47360 (IVB18_46765) 9906504..9906650 - 147 WP_211400134.1 histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-114)

Antitoxin

Antitoxin PemI-like

(1-61)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14552.64 Da        Isoelectric Point: 6.8587

>T214263 WP_247986891.1 NZ_CP082164:c9901939-9901535 [Bradyrhizobium sp. 186]
VKAFFDSSILVYTATSDPRKQQAAACLSGGGYVSVQVLNEFVHVARRKLRTDWPQIEFALQQFRVSLVDVVPITLNTHAG
ALALARNHGFAFYDALIVAAAIEAGCDTLYSEDMQHGRNVGGLTIVNPFLGNMP

Download         Length: 405 bp

>T214263 NZ_CP110017:c3265656-3265360 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGAACATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8809.90 Da        Isoelectric Point: 4.9011

>AT214263 WP_247986892.1 NZ_CP082164:c9902169-9901936 [Bradyrhizobium sp. 186]
VQVSKWGNSLAVRLPKALVEELGLKEGDELDVVASRKGTIEVETKEERRRRAIENLASLNWTLPADYKFDRDEANER

Download         Length: 234 bp

>AT214263 NZ_CP110017:c3265358-3264963 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References