Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 7888942..7889516 Replicon chromosome
Accession NZ_CP082164
Organism Bradyrhizobium sp. 186

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag IVB18_RS38040 Protein ID WP_247985380.1
Coordinates 7889163..7889516 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag IVB18_RS38035 Protein ID WP_247985379.1
Coordinates 7888942..7889166 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IVB18_RS38025 (IVB18_37535) 7884282..7887419 - 3138 WP_247985377.1 efflux RND transporter permease subunit -
IVB18_RS38030 (IVB18_37540) 7887659..7888765 - 1107 WP_247985378.1 efflux RND transporter periplasmic adaptor subunit -
IVB18_RS38035 (IVB18_37545) 7888942..7889166 + 225 WP_247985379.1 antitoxin MazE family protein Antitoxin
IVB18_RS38040 (IVB18_37550) 7889163..7889516 + 354 WP_247985380.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
IVB18_RS38045 (IVB18_37555) 7889587..7890930 - 1344 WP_247985381.1 MFS transporter -
IVB18_RS38050 (IVB18_37560) 7891011..7891439 + 429 Protein_7602 DUF2809 domain-containing protein -
IVB18_RS38055 (IVB18_37565) 7891693..7892853 - 1161 WP_247985382.1 crosslink repair DNA glycosylase YcaQ family protein -
IVB18_RS38060 (IVB18_37570) 7892983..7893231 - 249 WP_247991825.1 hypothetical protein -
IVB18_RS38065 (IVB18_37575) 7893353..7893598 - 246 WP_247991826.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-107)

Antitoxin

Antitoxin MazE-like

(11-73)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 12678.52 Da        Isoelectric Point: 6.3003

>T214261 WP_247985380.1 NZ_CP082164:7889163-7889516 [Bradyrhizobium sp. 186]
MKRGDIWTVAGGKDYAGKPRPVVIVQDDSFDATDSITICAFTTDRIEAPLFRLQVEPNDGNGLRAPSRLMVDKITTVPKS
KVATCIGRLDDEDVVRLNRAMLVFLGLAGSQRTAADG

Download         Length: 354 bp

>T214261 NZ_CP110017:c3002999-3002664 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8311.27 Da        Isoelectric Point: 10.4473

>AT214261 WP_247985379.1 NZ_CP082164:7888942-7889166 [Bradyrhizobium sp. 186]
MPTSSKAKSSRVKVRAHRDRLRAQGLRPIQIWVPDVRSASFRSEAHRQSLAVATSAHEPEDQAFIDAVSDWADE

Download         Length: 225 bp

>AT214261 NZ_CP110017:c3003247-3002999 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References