Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) AbkB-shpB/BrnT-BrnA
Location 1147212..1147788 Replicon chromosome
Accession NZ_CP082164
Organism Bradyrhizobium sp. 186

Toxin (Protein)


Gene name AbkB Uniprot ID -
Locus tag IVB18_RS05220 Protein ID WP_247988198.1
Coordinates 1147471..1147788 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID -
Locus tag IVB18_RS05215 Protein ID WP_247988197.1
Coordinates 1147212..1147451 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IVB18_RS05185 (IVB18_05155) 1142557..1143177 + 621 WP_247988191.1 LysE family translocator -
IVB18_RS05190 (IVB18_05160) 1143262..1144245 + 984 WP_247988192.1 DUF3592 domain-containing protein -
IVB18_RS05195 (IVB18_05165) 1144242..1145048 - 807 WP_247988193.1 N-formylglutamate amidohydrolase -
IVB18_RS05200 (IVB18_05170) 1145142..1146053 + 912 WP_247988194.1 transglutaminase family protein -
IVB18_RS05205 (IVB18_05175) 1146181..1146579 + 399 WP_247988195.1 gamma-glutamylcyclotransferase family protein -
IVB18_RS05210 (IVB18_05180) 1146576..1147139 - 564 WP_247988196.1 chlorite dismutase family protein -
IVB18_RS05215 (IVB18_05185) 1147212..1147451 - 240 WP_247988197.1 BrnA antitoxin family protein Antitoxin
IVB18_RS05220 (IVB18_05190) 1147471..1147788 - 318 WP_247988198.1 BrnT family toxin Toxin
IVB18_RS05225 (IVB18_05195) 1147948..1149948 + 2001 WP_247988199.1 DNA primase -
IVB18_RS05230 (IVB18_05200) 1150327..1152483 + 2157 WP_247988200.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(14-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(32-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12152.72 Da        Isoelectric Point: 10.9347

>T214256 WP_247988198.1 NZ_CP082164:c1147788-1147471 [Bradyrhizobium sp. 186]
MSDFNLFAPAGFEWDEGKSRANLIKHSISFDDASQIFYGPVVLKRSNRNGEERWIAIGEFNDRILTVIFARRNESIRIIS
ARRPRPNEKRAYREASMGRSPQGKH

Download         Length: 318 bp

>T214256 NZ_CP110017:2166588-2166962 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9243.50 Da        Isoelectric Point: 5.1832

>AT214256 WP_247988197.1 NZ_CP082164:c1147451-1147212 [Bradyrhizobium sp. 186]
MTDEELEASIANDPDWAEFKDIDWSDAVLVVPPKKKAISIRVDEDVLDFFKREGEGYQRRMNAVLRSYMQQRAKPKKRA

Download         Length: 240 bp

>AT214256 NZ_CP110017:2166131-2166499 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References