Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 889426..890083 Replicon chromosome
Accession NZ_CP082154
Organism Klebsiella pneumoniae strain Kp11-81

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag K6977_RS04165 Protein ID WP_002916310.1
Coordinates 889426..889836 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag K6977_RS04170 Protein ID WP_002916312.1
Coordinates 889817..890083 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6977_RS04145 (K6977_04140) 885426..887159 - 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -
K6977_RS04150 (K6977_04145) 887165..887878 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K6977_RS04155 (K6977_04150) 887901..888797 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
K6977_RS04160 (K6977_04155) 888898..889419 + 522 WP_002916308.1 flavodoxin FldB -
K6977_RS04165 (K6977_04160) 889426..889836 - 411 WP_002916310.1 protein YgfX Toxin
K6977_RS04170 (K6977_04165) 889817..890083 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
K6977_RS04175 (K6977_04170) 890329..891312 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
K6977_RS04180 (K6977_04175) 891463..892122 - 660 WP_002916317.1 hemolysin III family protein -
K6977_RS04185 (K6977_04180) 892286..892597 - 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
K6977_RS04190 (K6977_04185) 892647..893375 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
K6977_RS04195 (K6977_04190) 893494..894927 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T214230 WP_002916310.1 NZ_CP082154:c889836-889426 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T214230 NZ_CP110016:2166584-2166958 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT214230 WP_002916312.1 NZ_CP082154:c890083-889817 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT214230 NZ_CP110016:2166127-2166495 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References