Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3976499..3977156 Replicon chromosome
Accession NZ_CP082147
Organism Enterobacter cloacae complex sp. strain ECL42

Toxin (Protein)


Gene name cptA Uniprot ID A0A2W0G6Z0
Locus tag K6966_RS19150 Protein ID WP_014885136.1
Coordinates 3976499..3976909 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag K6966_RS19155 Protein ID WP_010435322.1
Coordinates 3976890..3977156 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6966_RS19130 (K6966_19130) 3972493..3974226 - 1734 WP_023331239.1 single-stranded-DNA-specific exonuclease RecJ -
K6966_RS19135 (K6966_19135) 3974232..3974945 - 714 WP_014885133.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K6966_RS19140 (K6966_19140) 3974974..3975870 - 897 WP_014885134.1 site-specific tyrosine recombinase XerD -
K6966_RS19145 (K6966_19145) 3975972..3976493 + 522 WP_014885135.1 flavodoxin FldB -
K6966_RS19150 (K6966_19150) 3976499..3976909 - 411 WP_014885136.1 protein YgfX Toxin
K6966_RS19155 (K6966_19155) 3976890..3977156 - 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
K6966_RS19160 (K6966_19160) 3977451..3978431 + 981 WP_014885137.1 tRNA-modifying protein YgfZ -
K6966_RS19165 (K6966_19165) 3978516..3979175 - 660 WP_023331242.1 hemolysin III family protein -
K6966_RS19170 (K6966_19170) 3979441..3980172 + 732 WP_058689873.1 MurR/RpiR family transcriptional regulator -
K6966_RS19175 (K6966_19175) 3980289..3981722 + 1434 WP_014885140.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16135.04 Da        Isoelectric Point: 10.7510

>T214225 WP_014885136.1 NZ_CP082147:c3976909-3976499 [Enterobacter cloacae complex sp.]
VVLWQSDLRVSWRSQWMSLMLHGLVAAIVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNSGMMLRLRNVDGGRCQHLWLAADSMDASEWRDLRRMLLQQPTQE

Download         Length: 411 bp

>T214225 NZ_CP110016:c1501340-1501146 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT214225 WP_010435322.1 NZ_CP082147:c3977156-3976890 [Enterobacter cloacae complex sp.]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT214225 NZ_CP110016:1500969-1501147 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W0G6Z0

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References