Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA(toxin)
Location 3186308..3187414 Replicon chromosome
Accession NZ_CP082147
Organism Enterobacter cloacae complex sp. strain ECL42

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag K6966_RS15195 Protein ID WP_058691085.1
Coordinates 3186308..3186838 (+) Length 177 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag K6966_RS15200 Protein ID WP_058691086.1
Coordinates 3186977..3187414 (+) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6966_RS15170 (K6966_15170) 3182133..3183065 - 933 WP_023330920.1 tRNA dihydrouridine(16) synthase DusC -
K6966_RS15175 (K6966_15175) 3183234..3183629 + 396 WP_058691084.1 CidA/LrgA family protein -
K6966_RS15180 (K6966_15180) 3183626..3184321 + 696 WP_014884559.1 CidB/LrgB family autolysis modulator -
K6966_RS15185 (K6966_15185) 3184451..3185335 + 885 WP_014884560.1 cytidine deaminase -
K6966_RS15190 (K6966_15190) 3185463..3186176 + 714 WP_032636024.1 outer membrane permeability protein SanA -
K6966_RS15195 (K6966_15195) 3186308..3186838 + 531 WP_058691085.1 hypothetical protein Toxin
K6966_RS15200 (K6966_15200) 3186977..3187414 + 438 WP_058691086.1 helix-turn-helix transcriptional regulator Antitoxin
K6966_RS15205 (K6966_15205) 3187452..3188462 - 1011 WP_013097952.1 galactose/methyl galactoside ABC transporter permease MglC -
K6966_RS15210 (K6966_15210) 3188478..3189998 - 1521 WP_014884563.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
K6966_RS15215 (K6966_15215) 3190078..3191076 - 999 WP_014884564.1 galactose/glucose ABC transporter substrate-binding protein MglB -
K6966_RS15220 (K6966_15220) 3191372..3192394 - 1023 WP_014884565.1 HTH-type transcriptional regulator GalS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 177 a.a.        Molecular weight: 19575.80 Da        Isoelectric Point: 4.1958

>T214224 WP_058691085.1 NZ_CP082147:3186308-3186838 [Enterobacter cloacae complex sp.]
METLTVQAYLHEVWTDIALITFPGSENNDWNTTQLNYRTEYAINFLDYDDLHAVTLNHPVSLFFNDHGNPGWLRFIDDII
PAGASRRYWINALGISELPLSQQNFLLLKFGTMSPVGNLRIKESVPEWNEFASAKTFTVTDVIERAADFLDYAQERGAAA
GGATGAGGVDSPFDVA

Download         Length: 531 bp

>T214224 NZ_CP110016:c1309807-1309700 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 16377.73 Da        Isoelectric Point: 10.4647

>AT214224 WP_058691086.1 NZ_CP082147:3186977-3187414 [Enterobacter cloacae complex sp.]
MKIPDKTESEFLQTLARIRSANGRRHHDDAEDPDKLTQVNRQRVSPSLTRVDTRDRQDLLHAAIRDILLGKITQGEALRK
LRVEVLGLKQDEYAKLVSVSRKTLSDVENNRGNYSADIINKIFKPFGLQTGLVPISKSLIASLFS

Download         Length: 438 bp

>AT214224 NZ_CP110016:1309854-1309920 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References