Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3510295..3510923 Replicon chromosome
Accession NZ_CP082141
Organism Erwinia persicina strain Cp2

Toxin (Protein)


Gene name Hha Uniprot ID D2T444
Locus tag K6L24_RS16210 Protein ID WP_004156337.1
Coordinates 3510705..3510923 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A3S7S5Y4
Locus tag K6L24_RS16205 Protein ID WP_062744996.1
Coordinates 3510295..3510675 (+) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6L24_RS16175 (K6L24_16175) 3505474..3505617 + 144 WP_222681648.1 type B 50S ribosomal protein L36 -
K6L24_RS16180 (K6L24_16180) 3505879..3506910 + 1032 WP_062745004.1 hypothetical protein -
K6L24_RS16185 (K6L24_16185) 3506951..3507829 - 879 WP_062745002.1 metal ABC transporter substrate-binding protein -
K6L24_RS16190 (K6L24_16190) 3507826..3508695 - 870 WP_062745000.1 metal ABC transporter permease -
K6L24_RS16195 (K6L24_16195) 3508692..3509381 - 690 WP_118665845.1 ATP-binding cassette domain-containing protein -
K6L24_RS16200 (K6L24_16200) 3509794..3510147 + 354 WP_062744998.1 hypothetical protein -
K6L24_RS16205 (K6L24_16205) 3510295..3510675 + 381 WP_062744996.1 Hha toxicity modulator TomB Antitoxin
K6L24_RS16210 (K6L24_16210) 3510705..3510923 + 219 WP_004156337.1 HHA domain-containing protein Toxin
K6L24_RS16220 (K6L24_16220) 3511215..3511529 + 315 WP_062744994.1 MGMT family protein -
K6L24_RS16225 (K6L24_16225) 3511558..3512115 - 558 WP_062744992.1 YbaY family lipoprotein -
K6L24_RS16230 (K6L24_16230) 3512343..3513203 + 861 WP_062744990.1 acyl-CoA thioesterase II -
K6L24_RS16235 (K6L24_16235) 3513285..3514586 - 1302 WP_118664527.1 ammonium transporter AmtB -
K6L24_RS16240 (K6L24_16240) 3514606..3514944 - 339 WP_007886947.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8627.06 Da        Isoelectric Point: 8.9007

>T214207 WP_004156337.1 NZ_CP082141:3510705-3510923 [Erwinia persicina]
MTDKLLTKTDYLMRLRRCRSIDTLERVIEKNKYELSDDELAVFYSAADHRLAELTMNKLYDKVPVAVWKFVR

Download         Length: 219 bp

>T214207 NZ_CP110015:2857045-2858118 [Escherichia coli]
ATGACAATCAGGAGTTACAAAAACTTAAATCTGGTCAGGGCAAATATCGAGACTGAATCCAGACAATTCATTGAAAATAA
AAACTATTCAATCCAATCAATTGGTCCTATGCCAGGGTCAAGGGCTGGGCTTCGGGTCGTATTTACCAGACCAGGGGTTA
ACTTGGCAACTGTGGACATTTTTTATAACGGGGACGGTTCGACTACAATTCAATATCTCACTGGAGCCAATCGTTCTCTG
GGCCAAGAGTTAGCGGATCATCTTTTTGAAACCATCAATCCTGCTGAATTTGAGCAGGTAAATATGGTACTGCAAGGATT
TGTAGAGACAAGCGTTCTACCTGTACTTGAGCTATCAGCAGATGAATCGCATATAGAGTTCAGAGAACACTCTCGTAACG
CTCATACCGTAGTGTGGAAAATTATTTCCACCAGCTATCAGGACGAATTGACTGTGAGCCTGCATATCACAACAGGTAAG
CTCCAGATTCAGGGCCGACCGCTGTCATGTTACAGAGTTTTCACGTTTAACTTGGCAGCCCTGCTTGATTTACAGGGTTT
GGAGAAAGTGCTAATCCGCCAGGAGGATGGTAAAGCTAATATTGTTCAACAGGAGGTTGCCCGCACTTACTTGCAGACTG
TAATGGCCGATGCTTACCCGCATCTCCACGTGACTGCCGAAAAATTGCTCGTTTCAGGGCTATGTGTTAAACTCGCCGCC
CCTGATTTGCCTGACTACTGTATGTTACTTTATCCTGAACTACGCACCATTGAAGGTGTCTTAAAAAGTAAGATGAGTGG
GTTAGGCATGCCAGTACAGCAGCCGGCAGGTTTTGGAACTTACTTTGATAAACCTGCTGCTCATTACATTCTGAAACCGC
AATTTGCAGCTACTCTTAGACCGGAACAGATTAACATCATCAGCACAGCCTATACTTTTTTTAATGTGGAACGTCATTCT
CTGTTCCACATGGAAACTGTGGTCGATGCCAGCCGTATGATTTCTGATATGGCCCGGTTGATGGGTAAAGCCACTAGAGC
GTGGGGAATAATCAAGGACTTATATATTGTTTGA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 14645.29 Da        Isoelectric Point: 4.5911

>AT214207 WP_062744996.1 NZ_CP082141:3510295-3510675 [Erwinia persicina]
MDEYSPRRHDIAQLKFLCENLYDESLATLGDSHHGWVNDPTSVANLQLNDLIEHIAAFTMNYKIKHIEDVDLISQVDEYL
DDTFTLFSNYGINVQDLQRWQKCAKRLFNIFAEECSTARTQASHSF

Download         Length: 381 bp

>AT214207 NZ_CP110015:2858111-2858482 [Escherichia coli]
TTGTTTGAAATCACCGGAATTAACGTCTCAGGGGCTCTAAAAGCTGTCGTTATGGCGACCGGCTTCGAGAACCCTTTGTC
CTCAGTTAATGAAATTGAGACGAAACTTTCTGCCCTACTGGGTAGTGAGACCACTGGTGAAATCCTTTTTGACCTCTTGT
GCGCTAACGGTCCAGAGTGGAACCGCTTCGTTACGCTGGAAATGAAATATGGCCGGATCATGCTGGATACGGCCAAAATT
ATTGATGAGCAGGACGTTCCGACACATATCCTGAGCAAACTGACTTTTACTTTACGTAATCATCCTGAGTACCTAGAAGC
CTCTGTTTTGTCTCCCGATGATGTACGCCAAGTCCTGTCAATGGATTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A831EPQ0

Antitoxin

Source ID Structure
AlphaFold DB A0A3S7S5Y4

References