Detailed information of TA system TA021420

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 4264838..4265472
• Replicon: chromosome
• Accession: NC_007778
• Organism: Rhodopseudomonas palustris HaA2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: RPB_RS18805
• Protein ID: WP_011442607.1
• Coordinates: 4264838..4265239 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: Q2ITN6
• Locus tag: RPB_RS18810
• Protein ID: WP_011442608.1
• Coordinates: 4265236..4265472 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RPB_RS18775	4260353..4260736	-	384	WP_011442602.1	hypothetical protein	-
RPB_RS18780	4261040..4261279	+	240	WP_041798870.1	hypothetical protein	-
RPB_RS18785	4261276..4262001	+	726	WP_011442603.1	Fic family protein	-
RPB_RS18790	4262250..4262678	+	429	WP_011442604.1	hypothetical protein	-
RPB_RS18795	4262865..4263347	-	483	Protein_3769	transcription elongation factor GreA	-
RPB_RS24720	4263490..4263651	-	162	WP_157038864.1	hypothetical protein	-
RPB_RS18800	4264268..4264681	-	414	WP_011442606.1	DUF2147 domain-containing protein	-
RPB_RS18805	4264838..4265239	-	402	WP_011442607.1	type II toxin-antitoxin system VapC family toxin	Toxin
RPB_RS18810	4265236..4265472	-	237	WP_011442608.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
RPB_RS18815	4265545..4266741	-	1197	WP_011442609.1	DUF559 domain-containing protein	-
RPB_RS18820	4267144..4268370	+	1227	WP_011442610.1	NADP-dependent isocitrate dehydrogenase	-
RPB_RS18825	4268573..4270282	-	1710	WP_041798348.1	Kef family K(+) transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (10-58)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 13924.01 Da
• Isoelectric Point: 7.8221

>T21420 WP_011442607.1 NC_007778:c4265239-4264838 [Rhodopseudomonas palustris HaA2]
VTRYLLDTNILSDLIRNPQGAAARRIAKVGEAGVCTSIIVASELRYGCAKSGSAKLSKAVGDLLGEIDVLPFEAPADAEY
GAIRSALESAGTPIGSNDLLIAAHAKSLGAIMVTANTQEFKRVRGLKVENWLA

Nucleotide

• Length: 402 bp

>T21420 NC_007778:c4265239-4264838 [Rhodopseudomonas palustris HaA2]
GTGACGCGCTACCTGCTGGACACCAACATCCTTTCCGATCTGATCCGGAATCCGCAGGGCGCGGCCGCGCGCCGCATCGC
CAAGGTCGGCGAAGCCGGCGTCTGCACCAGCATCATCGTTGCGTCCGAGCTGCGCTATGGCTGCGCCAAGAGTGGGTCGG
CCAAGCTGAGCAAGGCAGTCGGCGATCTGCTCGGCGAGATCGACGTGTTGCCGTTCGAGGCGCCGGCCGACGCCGAATAT
GGTGCCATCCGTTCGGCGCTGGAGTCCGCCGGGACGCCGATCGGCAGCAACGATCTGCTGATCGCCGCCCACGCGAAATC
GCTGGGCGCGATCATGGTCACGGCCAATACGCAGGAATTCAAGCGCGTCCGGGGATTGAAGGTCGAGAACTGGCTGGCGT
GA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8840.29 Da
• Isoelectric Point: 6.2206

>AT21420 WP_011442608.1 NC_007778:c4265472-4265236 [Rhodopseudomonas palustris HaA2]
MPVHRHVRLFRNGRNQAVRIPVEFELPGDEAIMHRDGDRLVIEPVRKRGLIALLASMPPLDEAFPEIDDPAPAPEKIL

Nucleotide

• Length: 237 bp

>AT21420 NC_007778:c4265472-4265236 [Rhodopseudomonas palustris HaA2]
ATGCCGGTCCACCGACACGTCCGGTTGTTTCGCAACGGCAGGAACCAGGCGGTCCGCATTCCGGTGGAATTCGAATTGCC
CGGAGATGAAGCCATCATGCATCGGGACGGTGACCGTCTGGTGATCGAGCCGGTGCGTAAACGCGGTCTGATCGCCTTGT
TGGCATCGATGCCCCCGCTCGACGAGGCGTTTCCGGAGATTGACGATCCGGCGCCGGCGCCGGAGAAAATCCTGTGA

Structures

Antitoxin

• AlphaFold DB: Q2ITN6