Detailed information of TA system TA021419

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): BrnTA/BrnT-BrnA
• Location: 4003590..4004136
• Replicon: chromosome
• Accession: NC_007778
• Organism: Rhodopseudomonas palustris HaA2

Toxin (Protein)

• Gene name: brnT
• Uniprot ID: Q2IUB6
• Locus tag: RPB_RS17655
• Protein ID: WP_011442378.1
• Coordinates: 4003885..4004136 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: brnA
• Uniprot ID: Q2IUB7
• Locus tag: RPB_RS17650
• Protein ID: WP_011442377.1
• Coordinates: 4003590..4003892 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RPB_RS17635	3998763..4000160	-	1398	WP_011442374.1	hypothetical protein	-
RPB_RS17640	4000359..4001954	-	1596	WP_011442375.1	MFS transporter	-
RPB_RS17645	4002275..4003342	+	1068	WP_011442376.1	linear amide C-N hydrolase	-
RPB_RS17650	4003590..4003892	-	303	WP_011442377.1	BrnA antitoxin family protein	Antitoxin
RPB_RS17655	4003885..4004136	-	252	WP_011442378.1	BrnT family toxin	Toxin
RPB_RS17660	4004740..4005261	+	522	WP_041798845.1	hypothetical protein	-
RPB_RS17665	4005281..4006618	-	1338	WP_011442380.1	caspase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-77)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (25-95)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9377.70 Da
• Isoelectric Point: 7.2019

>T21419 WP_011442378.1 NC_007778:c4004136-4003885 [Rhodopseudomonas palustris HaA2]
MKILWDEHKRVVNLEAHGLDFADLDGAYFESAVIRPSYSGRYLAFGRLNADAVAVVFKPLGREAISVISLRPANRREREL
FDG

Nucleotide

• Length: 252 bp

>T21419 NC_007778:c4004136-4003885 [Rhodopseudomonas palustris HaA2]
ATGAAAATCCTGTGGGACGAGCACAAGCGCGTCGTCAATCTCGAGGCCCATGGTTTGGACTTTGCCGACCTCGACGGCGC
ATATTTCGAGAGCGCTGTGATCCGGCCTTCGTATTCCGGGCGCTATCTGGCATTCGGTCGATTGAATGCCGATGCAGTTG
CGGTGGTCTTCAAACCGCTGGGACGCGAAGCGATCAGCGTCATCAGTCTGCGGCCCGCCAACCGACGCGAAAGGGAGCTG
TTCGATGGCTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11400.98 Da
• Isoelectric Point: 10.4251

>AT21419 WP_011442377.1 NC_007778:c4003892-4003590 [Rhodopseudomonas palustris HaA2]
MAKKTLKTFQPDRGYTKEDWDEVGDNPEWTAEDFAKARPFAEVLPDLAASIRRGRGPNKAPTKKLVSLRLSREVIDKYKA
GGDGWQSRIDADLRRINKIK

Nucleotide

• Length: 303 bp

>AT21419 NC_007778:c4003892-4003590 [Rhodopseudomonas palustris HaA2]
ATGGCTAAGAAGACGTTGAAGACCTTCCAGCCCGACCGTGGCTACACCAAAGAGGACTGGGACGAAGTGGGCGACAATCC
GGAATGGACCGCCGAGGATTTCGCCAAGGCGCGTCCGTTCGCCGAAGTCCTCCCCGACCTCGCGGCCTCGATCCGGCGCG
GGCGCGGGCCGAACAAGGCGCCGACCAAGAAGCTGGTATCGCTGCGGCTGTCGCGCGAAGTGATCGACAAATACAAGGCC
GGCGGCGACGGCTGGCAATCGCGCATCGACGCGGATCTGCGGCGGATCAACAAGATCAAGTAG

Structures

Toxin

• AlphaFold DB: Q2IUB6

Antitoxin

• AlphaFold DB: Q2IUB7