Detailed information of TA system TA021418

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 2680336..2681037
• Replicon: chromosome
• Accession: NC_007778
• Organism: Rhodopseudomonas palustris HaA2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q2IXM3
• Locus tag: RPB_RS11725
• Protein ID: WP_011441222.1
• Coordinates: 2680336..2680758 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: Q2IXM2
• Locus tag: RPB_RS11730
• Protein ID: WP_011441223.1
• Coordinates: 2680783..2681037 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RPB_RS11700	2675414..2676151	+	738	WP_011441216.1	tetratricopeptide repeat protein	-
RPB_RS24575	2676386..2676526	-	141	WP_157038813.1	hypothetical protein	-
RPB_RS11705	2676675..2677133	-	459	WP_041798695.1	cupin domain-containing protein	-
RPB_RS11710	2677431..2677850	+	420	WP_041798214.1	secondary thiamine-phosphate synthase enzyme YjbQ	-
RPB_RS23815	2678109..2679509	+	1401	WP_011441220.1	HD domain-containing protein	-
RPB_RS11720	2679676..2680206	+	531	WP_049824745.1	HXXEE domain-containing protein	-
RPB_RS11725	2680336..2680758	-	423	WP_011441222.1	type II toxin-antitoxin system VapC family toxin	Toxin
RPB_RS11730	2680783..2681037	-	255	WP_011441223.1	plasmid stabilization protein	Antitoxin
RPB_RS11735	2681904..2682983	+	1080	WP_157038814.1	hypothetical protein	-
RPB_RS11745	2683716..2685077	+	1362	WP_011441225.1	RluA family pseudouridine synthase	-
RPB_RS11750	2685126..2685443	+	318	WP_011441226.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 14774.98 Da
• Isoelectric Point: 5.0829

>T21418 WP_011441222.1 NC_007778:c2680758-2680336 [Rhodopseudomonas palustris HaA2]
MILLDTNVVSEAIKPGPHPSVLAWLDVQAAETLFLSSITVAELLFGVGAMPDGKRKNLLAVRIDGLLDQFDRRVLHFDIP
AARCYADLAVKARAVGKGFPTPDGYIAAIAAAHGFSVASRDASAFDAAGLTVIDPWTASD

Nucleotide

• Length: 423 bp

>T21418 NC_007778:c2680758-2680336 [Rhodopseudomonas palustris HaA2]
ATGATCCTGCTGGACACCAACGTCGTCTCGGAAGCGATCAAACCCGGACCTCACCCGTCGGTTCTCGCCTGGCTCGACGT
TCAGGCGGCCGAGACCTTGTTTCTGTCCAGCATCACCGTGGCCGAACTTCTCTTCGGCGTCGGCGCGATGCCGGACGGCA
AGCGAAAGAACTTGCTGGCGGTTCGGATCGACGGCTTGCTGGACCAGTTCGACCGCCGTGTCCTGCACTTCGATATCCCT
GCGGCGCGGTGCTATGCCGATCTCGCCGTCAAGGCACGCGCGGTCGGAAAGGGCTTCCCCACGCCCGACGGCTATATCGC
CGCGATCGCCGCCGCACACGGCTTTAGTGTCGCGTCGCGCGACGCGAGTGCGTTCGACGCGGCCGGCCTGACCGTGATCG
ATCCCTGGACGGCGAGCGACTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9337.69 Da
• Isoelectric Point: 8.9326

>AT21418 WP_011441223.1 NC_007778:c2681037-2680783 [Rhodopseudomonas palustris HaA2]
MVAVTIRNLSDEAHRALKVRAAQHNRSAEAEMRAILEAAVRPEGRVRLGTALSDISRKMGLTNADIEALEQVRDTRPAEP
MKFE

Nucleotide

• Length: 255 bp

>AT21418 NC_007778:c2681037-2680783 [Rhodopseudomonas palustris HaA2]
ATGGTCGCCGTCACCATTCGCAACCTCTCCGACGAGGCGCATCGCGCCCTGAAGGTCCGCGCGGCGCAGCATAATCGCAG
CGCGGAGGCAGAGATGCGCGCCATTCTGGAAGCCGCCGTGCGCCCCGAGGGCCGCGTGCGGCTCGGCACCGCCTTGTCGG
ACATAAGCCGGAAAATGGGTCTCACCAATGCCGATATCGAAGCGCTCGAACAGGTCCGCGACACGCGTCCGGCCGAGCCG
ATGAAGTTTGAATGA

Structures

Toxin

• AlphaFold DB: Q2IXM3

Antitoxin

• AlphaFold DB: Q2IXM2