Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 50516..51351 Replicon chromosome
Accession NZ_CP082129
Organism Escherichia coli strain NDM_11.16372

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag K5P77_RS00255 Protein ID WP_001565141.1
Coordinates 50516..50893 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag K5P77_RS00260 Protein ID WP_001565140.1
Coordinates 50983..51351 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5P77_RS00230 (45881) 45881..46804 - 924 WP_000535961.1 carboxylate/amino acid/amine transporter -
K5P77_RS00235 (46915) 46915..48099 - 1185 WP_001172898.1 sugar efflux transporter -
K5P77_RS24330 (48496) 48496..48657 - 162 Protein_47 virulence RhuM family protein -
K5P77_RS00240 (48895) 48895..49737 - 843 WP_001565143.1 DUF4942 domain-containing protein -
K5P77_RS00245 (49822) 49822..50019 - 198 WP_000839256.1 DUF957 domain-containing protein -
K5P77_RS00250 (50031) 50031..50519 - 489 WP_001565142.1 DUF5983 family protein -
K5P77_RS00255 (50516) 50516..50893 - 378 WP_001565141.1 TA system toxin CbtA family protein Toxin
K5P77_RS00260 (50983) 50983..51351 - 369 WP_001565140.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
K5P77_RS00265 (51426) 51426..51647 - 222 WP_000692303.1 DUF987 domain-containing protein -
K5P77_RS00270 (51716) 51716..52192 - 477 WP_001186771.1 RadC family protein -
K5P77_RS00275 (52208) 52208..52693 - 486 WP_001737493.1 antirestriction protein -
K5P77_RS00280 (52785) 52785..53603 - 819 WP_001234749.1 DUF932 domain-containing protein -
K5P77_RS00285 (53694) 53694..53927 - 234 WP_001117560.1 DUF905 family protein -
K5P77_RS00290 (53998) 53998..55407 - 1410 Protein_58 autotransporter adhesin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14246.27 Da        Isoelectric Point: 7.2920

>T214174 WP_001565141.1 NZ_CP082129:c50893-50516 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SICPRSQLINSIDILRARRATGLMTRDNYRMVNNITQGKHPEAQQ

Download         Length: 378 bp

>T214174 NZ_CP110014:1597894-1598070 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13604.41 Da        Isoelectric Point: 6.7389

>AT214174 WP_001565140.1 NZ_CP082129:c51351-50983 [Escherichia coli]
VSDTLPGTTHPDDNHDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFALLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT214174 NZ_CP110014:1598116-1598532 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References