21417

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/AbrB(antitoxin)
Location 3898924..3899564 Replicon chromosome
Accession NC_007777
Organism Frankia sp. CcI3

Toxin (Protein)


Gene name vapC Uniprot ID Q2J7U3
Locus tag FRANCCI3_RS16550 Protein ID WP_011437676.1
Coordinates 3899157..3899564 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1X1PWZ9
Locus tag FRANCCI3_RS16545 Protein ID WP_035733247.1
Coordinates 3898924..3899160 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FRANCCI3_RS16525 3893947..3895608 - 1662 WP_011437671.1 potassium-transporting ATPase subunit KdpA -
FRANCCI3_RS23595 3895609..3895698 - 90 WP_023840421.1 K(+)-transporting ATPase subunit F -
FRANCCI3_RS16530 3896185..3896937 - 753 WP_035958678.1 response regulator transcription factor -
FRANCCI3_RS16535 3897034..3897885 - 852 WP_011437673.1 DUF72 domain-containing protein -
FRANCCI3_RS16545 3898924..3899160 + 237 WP_035733247.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
FRANCCI3_RS16550 3899157..3899564 + 408 WP_011437676.1 type II toxin-antitoxin system VapC family toxin Toxin
FRANCCI3_RS16555 3899962..3900321 - 360 WP_011437677.1 helix-turn-helix transcriptional regulator -
FRANCCI3_RS16560 3900465..3900860 + 396 WP_011437678.1 NAD(P)-binding domain-containing protein -
FRANCCI3_RS16565 3900857..3901765 + 909 WP_011437679.1 NAD(P)-dependent oxidoreductase -
FRANCCI3_RS16570 3902288..3903724 + 1437 WP_011437680.1 putative DNA binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-121)

Antitoxin

SpoVT-AbrB domain

(4-43)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14170.35 Da        Isoelectric Point: 9.9320

>T21417 WP_011437676.1 NC_007777:3899157-3899564 [Frankia casuarinae]
VTIAVDTSVAVPLLVRSHTHHADVVQWWGGRELALSGYALVETYSVLTRMPGDARLSGPDAARLLDVRFTAPLTLSGPHA
RKVHATLSRVGIVGGAVYDGLVALAAKEHGLALATRDARARGTYDALGVKVIVVA

Download         Length: 408 bp

>T21417 NC_007777:3899157-3899564 [Frankia casuarinae]
GTGACCATTGCGGTCGACACGAGTGTCGCGGTTCCGCTCCTGGTACGTTCGCACACGCACCACGCGGATGTGGTGCAATG
GTGGGGCGGGCGGGAGCTTGCGCTGAGTGGGTATGCGCTGGTGGAGACCTATTCGGTACTCACCAGAATGCCCGGCGACG
CGAGACTGTCCGGGCCGGACGCCGCGCGTCTGCTCGACGTGCGCTTCACTGCACCGTTAACGTTGAGCGGACCGCATGCG
CGGAAGGTTCACGCGACGTTGAGTCGCGTCGGTATTGTTGGGGGCGCCGTCTACGATGGGCTGGTGGCTTTGGCTGCCAA
GGAGCACGGCCTGGCCCTCGCGACGAGGGATGCTCGCGCACGCGGGACCTATGACGCGCTTGGAGTCAAGGTCATTGTTG
TCGCTTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8171.40 Da        Isoelectric Point: 4.2985

>AT21417 WP_035733247.1 NC_007777:3898924-3899160 [Frankia casuarinae]
MEAVVDQAGRIVLPKLLREALGLFPGTKVDISPYGAGVQIVPAGRTARLVEEDGVLVSAGDTPVDDDILFGLIDAGRR

Download         Length: 237 bp

>AT21417 NC_007777:3898924-3899160 [Frankia casuarinae]
ATGGAAGCCGTTGTCGATCAGGCGGGCCGGATCGTGTTGCCCAAGCTCCTCCGCGAGGCGCTGGGCCTGTTCCCGGGAAC
GAAGGTGGACATCTCGCCCTATGGCGCCGGTGTCCAGATCGTGCCTGCCGGCAGGACCGCGCGCCTCGTCGAGGAGGATG
GTGTGCTCGTGTCAGCCGGCGATACGCCCGTCGACGACGACATCCTGTTCGGCCTCATTGACGCAGGCCGCAGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q2J7U3

Antitoxin

Source ID Structure
AlphaFold DB A0A1X1PWZ9

References