Detailed information of TA system TA021413

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2018641..2019296
• Replicon: chromosome
• Accession: NC_007777
• Organism: Frankia sp. CcI3

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q2JCD5
• Locus tag: FRANCCI3_RS08450
• Protein ID: WP_011436119.1
• Coordinates: 2018641..2019051 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FRANCCI3_RS08455
• Protein ID: WP_011436120.1
• Coordinates: 2019048..2019296 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FRANCCI3_RS26770	2015040..2015297	-	258	WP_152569697.1	hypothetical protein	-
FRANCCI3_RS08435	2015894..2016103	-	210	WP_035958795.1	hypothetical protein	-
FRANCCI3_RS23305	2016283..2017251	+	969	WP_049760878.1	hypothetical protein	-
FRANCCI3_RS08445	2017552..2018241	-	690	WP_011436118.1	response regulator transcription factor	-
FRANCCI3_RS08450	2018641..2019051	-	411	WP_011436119.1	type II toxin-antitoxin system VapC family toxin	Toxin
FRANCCI3_RS08455	2019048..2019296	-	249	WP_011436120.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
FRANCCI3_RS08460	2019479..2020636	-	1158	WP_108913810.1	aminotransferase class V-fold PLP-dependent enzyme	-
FRANCCI3_RS08465	2020852..2022474	-	1623	Protein_1712	recombinase family protein	-
FRANCCI3_RS08470	2022523..2022795	-	273	WP_011436123.1	hypothetical protein	-
FRANCCI3_RS26775	2022879..2023046	-	168	WP_157493277.1	hypothetical protein	-
FRANCCI3_RS08480	2023189..2023884	-	696	WP_011436124.1	recombinase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-127)

Antitoxin

• SpoVT-AbrB domain (10-55)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 14931.81 Da
• Isoelectric Point: 4.2704

>T21413 WP_011436119.1 NC_007777:c2019051-2018641 [Frankia casuarinae]
VNCLLDTSTVVALLRNKPVGVRERYREAEASEDYLALSSVVLFELWYGVAKSAQVPENTERLRILLSGDLDLLDFDDEDA
RAAGEVRAVLEKAGTPIGAYDLLIAGQALRRGLTVVTANTSEFSRVTGLSWEDWTS

Nucleotide

• Length: 411 bp

>T21413 NC_007777:c2019051-2018641 [Frankia casuarinae]
GTGAACTGCCTCCTGGACACCAGCACTGTGGTCGCACTGCTGCGGAACAAGCCCGTCGGCGTGCGGGAACGGTACCGGGA
GGCCGAAGCGTCAGAGGATTATCTCGCGCTCTCGTCGGTCGTCTTGTTCGAGCTGTGGTACGGCGTGGCGAAGAGCGCTC
AGGTGCCGGAGAACACCGAGCGCCTGCGGATACTGCTCTCCGGTGACCTGGACCTGCTTGACTTCGATGACGAGGATGCC
CGTGCTGCCGGCGAGGTGCGCGCCGTCCTGGAGAAGGCCGGGACGCCGATTGGCGCCTACGATCTGTTGATCGCCGGGCA
GGCACTGCGGCGCGGGCTGACAGTCGTTACGGCGAACACCTCGGAGTTCAGCCGGGTCACCGGCCTGAGCTGGGAGGACT
GGACGAGCTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9192.41 Da
• Isoelectric Point: 4.7640

>AT21413 WP_011436120.1 NC_007777:c2019296-2019048 [Frankia casuarinae]
VADTAIARLFMHGRSQAVRLPKEFRLPGDRVRVRHMGDGVLLEPIASDVDAWFAELDRFVDVPLFEDGRNQPPTPAGEDF
FG

Nucleotide

• Length: 249 bp

>AT21413 NC_007777:c2019296-2019048 [Frankia casuarinae]
GTGGCGGACACGGCGATCGCGAGGCTCTTCATGCACGGCAGAAGCCAGGCAGTGCGGCTCCCGAAGGAGTTCCGGCTGCC
CGGTGACCGGGTGCGCGTCCGGCACATGGGAGACGGCGTGCTGCTAGAGCCGATCGCGTCCGATGTCGACGCCTGGTTCG
CCGAGCTGGACCGTTTCGTGGACGTGCCGCTGTTCGAGGACGGCAGGAACCAGCCGCCGACGCCCGCCGGGGAGGACTTC
TTCGGGTGA

Structures

Toxin

• AlphaFold DB: Q2JCD5