21412

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-YefM
Location 1734162..1734672 Replicon chromosome
Accession NC_007777
Organism Frankia sp. CcI3

Toxin (Protein)


Gene name relE Uniprot ID W9D8Z6
Locus tag FRANCCI3_RS07250 Protein ID WP_023840524.1
Coordinates 1734162..1734428 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A4Y8ME28
Locus tag FRANCCI3_RS07255 Protein ID WP_011435885.1
Coordinates 1734430..1734672 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FRANCCI3_RS07220 1729217..1730254 + 1038 WP_041257824.1 Nif3-like dinuclear metal center hexameric protein -
FRANCCI3_RS07225 1730372..1731115 + 744 WP_011435879.1 HalX domain-containing protein -
FRANCCI3_RS07230 1731165..1732301 + 1137 WP_011435880.1 bifunctional RNase H/acid phosphatase -
FRANCCI3_RS07235 1732358..1732744 - 387 WP_011435881.1 hypothetical protein -
FRANCCI3_RS07240 1732737..1733636 - 900 WP_011435882.1 hypothetical protein -
FRANCCI3_RS07245 1733730..1733972 - 243 WP_023840525.1 helix-turn-helix domain-containing protein -
FRANCCI3_RS07250 1734162..1734428 - 267 WP_023840524.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FRANCCI3_RS07255 1734430..1734672 - 243 WP_011435885.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FRANCCI3_RS07260 1735260..1735811 + 552 WP_011435886.1 DUF1049 domain-containing protein -
FRANCCI3_RS07265 1735887..1736501 + 615 WP_011435887.1 PaaI family thioesterase -
FRANCCI3_RS23275 1736879..1738819 + 1941 WP_011435888.1 serine/threonine protein kinase -
FRANCCI3_RS07275 1738977..1739276 + 300 WP_011435889.1 GlsB/YeaQ/YmgE family stress response membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-64)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 9939.60 Da        Isoelectric Point: 11.9551

>T21412 WP_023840524.1 NC_007777:c1734428-1734162 [Frankia casuarinae]
VAHTVEWATAALRELRKLDASAARRILIAVTRLAAEPRPSGARALTGQPTGILRIRVGEYRVIYQVDHTRVLVTIVHVAH
RREVYRHL

Download         Length: 267 bp

>T21412 NC_007777:c1734428-1734162 [Frankia casuarinae]
GTGGCGCACACCGTCGAGTGGGCGACTGCGGCGCTGCGAGAGCTGCGCAAGCTCGACGCCTCCGCCGCTCGACGGATCCT
GATCGCGGTGACACGACTCGCGGCGGAACCCCGCCCCTCCGGGGCCCGGGCCCTCACCGGCCAACCCACCGGGATACTGC
GGATCAGAGTTGGTGAATATCGGGTGATCTACCAAGTCGACCACACCCGCGTTCTCGTCACGATCGTTCACGTCGCCCAT
CGACGTGAGGTGTACCGGCACCTCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8717.78 Da        Isoelectric Point: 4.4734

>AT21412 WP_011435885.1 NC_007777:c1734672-1734430 [Frankia casuarinae]
MPISEARDHLGEIVSKAEHARERIVLTRHGRAVAAVISIEDLRELEAAEDEADLAVAREALAAEEPRVPHADVLAEFGLN

Download         Length: 243 bp

>AT21412 NC_007777:c1734672-1734430 [Frankia casuarinae]
ATGCCGATCAGCGAGGCACGCGACCACCTCGGCGAGATCGTCTCCAAGGCGGAGCACGCCCGGGAGCGGATCGTCCTGAC
CCGTCACGGTCGCGCGGTCGCGGCAGTAATCTCCATAGAAGATCTCCGTGAGCTGGAAGCGGCAGAGGACGAAGCGGATC
TCGCCGTCGCCCGAGAGGCGCTGGCCGCCGAGGAGCCTCGCGTACCCCATGCCGACGTCCTCGCCGAGTTCGGCCTGAAC
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W9D8Z6

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y8ME28

References