214100

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 5059598..5060124 Replicon chromosome
Accession NZ_CP082041
Organism Klebsiella pneumoniae strain KP19-2196

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag K6165_RS25055 Protein ID WP_000323025.1
Coordinates 5059837..5060124 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag K6165_RS25050 Protein ID WP_000534858.1
Coordinates 5059598..5059837 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6165_RS25025 5054660..5055364 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
K6165_RS25030 5055596..5056936 + 1341 WP_000589001.1 ISNCY family transposase -
K6165_RS25035 5057357..5057668 + 312 Protein_4914 transposase -
K6165_RS25045 5059012..5059335 + 324 WP_224948387.1 cation transporter dimerization domain-containing protein -
K6165_RS30085 5059469..5059573 - 105 Protein_4917 hypothetical protein -
K6165_RS25050 5059598..5059837 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
K6165_RS25055 5059837..5060124 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
K6165_RS25060 5060196..5060354 + 159 WP_004181898.1 type I toxin-antitoxin system Hok family toxin -
K6165_RS25065 5060957..5061931 + 975 WP_004181899.1 hypothetical protein -
K6165_RS25070 5062129..5062506 - 378 WP_004181901.1 hypothetical protein -
K6165_RS25075 5063196..5064263 + 1068 WP_004181903.1 hypothetical protein -
K6165_RS25080 5064419..5064766 + 348 WP_004181904.1 hypothetical protein -
K6165_RS25085 5064845..5065078 + 234 WP_004181905.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - iucA / iucB / iucC / iucD / iutA / rmpA 5042504..5193414 150910


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T214100 WP_000323025.1 NZ_CP082041:5059837-5060124 [Klebsiella pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T214100 NZ_CP109963:2004739-2004841 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT214100 WP_000534858.1 NZ_CP082041:5059598-5059837 [Klebsiella pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT214100 NZ_CP109963:c2004848-2004703 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References