Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 5059598..5060124 Replicon chromosome
Accession NZ_CP082041
Organism Klebsiella pneumoniae strain KP19-2196

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag K6165_RS25055 Protein ID WP_000323025.1
Coordinates 5059837..5060124 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag K6165_RS25050 Protein ID WP_000534858.1
Coordinates 5059598..5059837 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6165_RS25025 5054660..5055364 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
K6165_RS25030 5055596..5056936 + 1341 WP_000589001.1 ISNCY family transposase -
K6165_RS25035 5057357..5057668 + 312 Protein_4914 transposase -
K6165_RS25045 5059012..5059335 + 324 WP_224948387.1 cation transporter dimerization domain-containing protein -
K6165_RS30085 5059469..5059573 - 105 Protein_4917 hypothetical protein -
K6165_RS25050 5059598..5059837 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
K6165_RS25055 5059837..5060124 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
K6165_RS25060 5060196..5060354 + 159 WP_004181898.1 type I toxin-antitoxin system Hok family toxin -
K6165_RS25065 5060957..5061931 + 975 WP_004181899.1 hypothetical protein -
K6165_RS25070 5062129..5062506 - 378 WP_004181901.1 hypothetical protein -
K6165_RS25075 5063196..5064263 + 1068 WP_004181903.1 hypothetical protein -
K6165_RS25080 5064419..5064766 + 348 WP_004181904.1 hypothetical protein -
K6165_RS25085 5064845..5065078 + 234 WP_004181905.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - iucA / iucB / iucC / iucD / iutA / rmpA 5042504..5193414 150910


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T214100 WP_000323025.1 NZ_CP082041:5059837-5060124 [Klebsiella pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T214100 NZ_CP109963:2004739-2004841 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT214100 WP_000534858.1 NZ_CP082041:5059598-5059837 [Klebsiella pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT214100 NZ_CP109963:c2004848-2004703 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References