Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 622087..622661 Replicon plasmid p42f
Accession NC_007766
Organism Rhizobium etli CFN 42

Toxin (Protein)


Gene name vapC Uniprot ID Q2JY93
Locus tag RHE_RS29330 Protein ID WP_011428857.1
Coordinates 622087..622452 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID S5SXW7
Locus tag RHE_RS29335 Protein ID WP_011428858.1
Coordinates 622446..622661 (-) Length 72 a.a.

Genomic Context

RHE_RS29310RHE_RS29315RHE_RS29320RHE_RS29355RHE_RS33055RHE_RS33930RHE_RS29325RHE_RS29330RHE_RS29335RHE_RS29340RHE_RS29345RHE_RS29350
Location: 618893..619216 (324 bp)
Type: Others
Protein ID: WP_042120070.1
Location: 619203..619673 (471 bp)
Type: Others
Protein ID: WP_042120034.1
Location: 620260..620501 (242 bp)
Type: Others
Protein ID: Protein_582
Location: 625887..626321 (435 bp)
Type: Others
Protein ID: WP_011428862.1
Location: 617970..618686 (717 bp)
Type: Others
Protein ID: WP_166486964.1
Location: 621174..621314 (141 bp)
Type: Others
Protein ID: WP_166486961.1
Location: 621489..621800 (312 bp)
Type: Others
Protein ID: WP_011428856.1
Location: 622087..622452 (366 bp)
Type: Toxin
Protein ID: WP_011428857.1
Location: 622446..622661 (216 bp)
Type: Antitoxin
Protein ID: WP_011428858.1
Location: 622982..623665 (684 bp)
Type: Others
Protein ID: WP_011428859.1
Location: 624036..625082 (1047 bp)
Type: Others
Protein ID: WP_011428860.1
Location: 625079..625801 (723 bp)
Type: Others
Protein ID: WP_011428861.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
RHE_RS33055617970..618686-717WP_166486964.1formate dehydrogenase oxidoreductase-
RHE_RS29310618893..619216+324WP_042120070.1hypothetical protein-
RHE_RS29315619203..619673+471WP_042120034.1hypothetical protein-
RHE_RS29320620260..620501+242Protein_582hypothetical protein-
RHE_RS33930621174..621314-141WP_166486961.1hypothetical protein-
RHE_RS29325621489..621800-312WP_011428856.1hypothetical protein-
RHE_RS29330622087..622452-366WP_011428857.1type II toxin-antitoxin system VapC family toxinToxin
RHE_RS29335622446..622661-216WP_011428858.1ribbon-helix-helix domain-containing proteinAntitoxin
RHE_RS29340622982..623665-684WP_011428859.1redoxin domain-containing protein-
RHE_RS29345624036..625082-1047WP_011428860.1S-adenosylmethionine:tRNA ribosyltransferase-isomerase-
RHE_RS29350625079..625801-723WP_011428861.1SDR family oxidoreductase-
RHE_RS29355625887..626321+435WP_011428862.1redox-sensitive transcriptional activator SoxR-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid-htpB1..642517642517


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-106)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-40)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13585.93 Da        Isoelectric Point: 7.2026

>T21410 WP_011428857.1 NC_007766:c622452-622087 [Rhizobium etli CFN 42]
MVKSLFDTNVLIDYLNAVPQARDELRRYPEKAISIITWMEVLVGAKPEVAIGTRAFLAGFAVIAVDNAIAERAVSLRQLH
RIKLPDAIIWATANVHSMLLITRNTKDFPGEMPDIRVPYEI

Download         Length: 366 bp

>T21410 NC_007766:c622452-622087 [Rhizobium etli CFN 42]
ATGGTAAAGTCTCTGTTCGACACTAATGTCTTGATTGATTATCTCAACGCAGTTCCACAAGCGCGAGACGAACTGAGGAG
ATATCCCGAAAAGGCGATTAGCATTATCACCTGGATGGAGGTTCTCGTCGGTGCCAAGCCTGAGGTGGCAATCGGAACGC
GCGCTTTCCTGGCCGGCTTTGCAGTCATCGCTGTCGATAACGCCATAGCCGAACGAGCAGTTTCTCTGCGACAACTTCAT
CGTATCAAGCTTCCAGATGCCATCATCTGGGCAACGGCCAATGTTCACTCGATGTTGCTGATTACCCGAAATACGAAGGA
TTTCCCTGGTGAAATGCCGGACATCCGAGTGCCATACGAAATTTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8233.40 Da        Isoelectric Point: 6.3273

>AT21410 WP_011428858.1 NC_007766:c622661-622446 [Rhizobium etli CFN 42]
MRTLVDIGDPEVKALDRLAQREKMSRAALIRKAINDFLARNNADIEAEAFGLWGDRKIDGLAYQENMRREW

Download         Length: 216 bp

>AT21410 NC_007766:c622661-622446 [Rhizobium etli CFN 42]
ATGAGAACGTTGGTAGATATCGGCGACCCAGAAGTCAAAGCGCTGGACCGGCTGGCACAGCGGGAAAAAATGTCGAGAGC
AGCGCTGATCCGAAAGGCGATCAATGACTTCCTGGCTAGGAACAATGCCGATATCGAAGCAGAAGCGTTCGGGCTCTGGG
GCGATCGAAAGATCGATGGTTTGGCCTATCAGGAAAACATGCGCCGCGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ2JY93

Antitoxin

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Source
ID
Structure
AlphaFold DBS5SXW7

References