Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4863629..4864145 Replicon chromosome
Accession NZ_CP082037
Organism Klebsiella pneumoniae strain KP18-2172

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag K6161_RS24010 Protein ID WP_002886902.1
Coordinates 4863629..4863913 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag K6161_RS24015 Protein ID WP_002886901.1
Coordinates 4863903..4864145 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6161_RS23985 4859113..4859376 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
K6161_RS23990 4859506..4859679 + 174 WP_002886906.1 hypothetical protein -
K6161_RS23995 4859682..4860425 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
K6161_RS24000 4860782..4862920 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
K6161_RS24005 4863161..4863625 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
K6161_RS24010 4863629..4863913 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6161_RS24015 4863903..4864145 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K6161_RS24020 4864223..4866133 - 1911 WP_004152270.1 PRD domain-containing protein -
K6161_RS24025 4866156..4867310 - 1155 WP_002886900.1 lactonase family protein -
K6161_RS24030 4867376..4868116 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T214073 WP_002886902.1 NZ_CP082037:c4863913-4863629 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T214073 NZ_CP109953:889918-890021 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT214073 WP_002886901.1 NZ_CP082037:c4864145-4863903 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT214073 NZ_CP109953:c890059-889788 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References