Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 874526..875180 Replicon chromosome
Accession NZ_CP082037
Organism Klebsiella pneumoniae strain KP18-2172

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag K6161_RS04460 Protein ID WP_004144731.1
Coordinates 874773..875180 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag K6161_RS04455 Protein ID WP_002916312.1
Coordinates 874526..874792 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6161_RS04430 869682..871115 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
K6161_RS04435 871234..871962 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
K6161_RS04440 872012..872323 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
K6161_RS04445 872487..873146 + 660 WP_002916317.1 hemolysin III family protein -
K6161_RS04450 873297..874280 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
K6161_RS04455 874526..874792 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
K6161_RS04460 874773..875180 + 408 WP_004144731.1 protein YgfX Toxin
K6161_RS04465 875187..875708 - 522 WP_002916308.1 flavodoxin FldB -
K6161_RS04470 875809..876705 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
K6161_RS04475 876728..877441 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K6161_RS04480 877447..879180 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T214061 WP_004144731.1 NZ_CP082037:874773-875180 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T214061 NZ_CP109948:c5353751-5353368 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT214061 WP_002916312.1 NZ_CP082037:874526-874792 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT214061 NZ_CP109948:c5353993-5353751 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References