Detailed information of TA system TA021405

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 2666966..2667567
• Replicon: chromosome
• Accession: NC_007712
• Organism: Sodalis glossinidius str. morsitans

Toxin (Protein)

• Gene name: doc
• Uniprot ID: Q2NSN8
• Locus tag: SGP1_RS14120
• Protein ID: WP_011411382.1
• Coordinates: 2667184..2667567 (+)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: A0A193QKG1
• Locus tag: SGP1_RS14115
• Protein ID: WP_041867580.1
• Coordinates: 2666966..2667187 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SGP1_RS14065	2662328..2662606	+	279	WP_041867028.1	hypothetical protein	-
SGP1_RS14070	2662624..2662827	+	204	WP_041867029.1	hypothetical protein	-
SGP1_RS14085 (SG1560)	2663341..2663742	-	402	WP_011411380.1	DUF1640 domain-containing protein	-
SGP1_RS33765	2664099..2664395	+	297	Protein_3038	Rha family transcriptional regulator	-
SGP1_RS33770	2664898..2665122	+	225	WP_243466028.1	Rha family transcriptional regulator	-
SGP1_RS33775	2665211..2665603	+	393	WP_243466029.1	hypothetical protein	-
SGP1_RS14105	2665615..2666152	+	538	Protein_3041	hypothetical protein	-
SGP1_RS14110 (SG1561)	2666251..2666565	+	315	WP_011411381.1	DUF4406 domain-containing protein	-
SGP1_RS29905	2666558..2666806	+	249	WP_148203520.1	hypothetical protein	-
SGP1_RS14115	2666966..2667187	+	222	WP_041867580.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
SGP1_RS14120 (SG1562)	2667184..2667567	+	384	WP_011411382.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
SGP1_RS33780	2667969..2668629	-	661	Protein_3046	phage portal protein	-
SGP1_RS33785	2668709..2670468	-	1760	Protein_3047	terminase family protein	-
SGP1_RS33790	2670627..2671690	+	1064	Protein_3048	GPO family capsid scaffolding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2652661..2698506	45845

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (4-120)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-52)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14146.13 Da
• Isoelectric Point: 5.5967

>T21405 WP_011411382.1 NC_007712:2667184-2667567 [Sodalis glossinidius str. 'morsitans']
MKWISAQEVIAFHDRLLAALPGVQRMPEPGRAEAIIYRVQNQLYYEGTEDIHELSAMYLVAISRGHIFNDGNKRTAFFVA
MAFLKRNGIDVRDEGDELEELTVSAAMGSVSSGDVAAVLRRLSINPH

Nucleotide

• Length: 384 bp

>T21405 NC_007712:2667184-2667567 [Sodalis glossinidius str. 'morsitans']
ATGAAATGGATCAGCGCCCAGGAGGTGATAGCGTTTCATGATCGCCTACTTGCAGCTTTGCCGGGCGTGCAGAGGATGCC
AGAACCGGGAAGAGCAGAGGCGATCATTTATCGTGTTCAGAACCAGCTGTACTATGAAGGCACTGAGGATATTCACGAAC
TCTCTGCGATGTATCTTGTCGCTATTTCGCGTGGCCATATCTTCAATGACGGCAATAAGCGAACCGCCTTTTTCGTTGCG
ATGGCTTTTTTAAAGCGCAATGGCATTGATGTCCGTGATGAAGGTGACGAACTGGAAGAACTGACGGTATCTGCAGCGAT
GGGTTCAGTAAGCAGCGGTGATGTTGCTGCTGTTTTGCGCCGACTATCCATCAATCCCCACTGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8117.07 Da
• Isoelectric Point: 4.7361

>AT21405 WP_041867580.1 NC_007712:2666966-2667187 [Sodalis glossinidius str. 'morsitans']
MRTYTTSQARQNIAEVMEAATAGEPVEITRRDGSAAVLISRDDFNTWQETKLDAEFAEIMGRHGCTIKALADR

Nucleotide

• Length: 222 bp

>AT21405 NC_007712:2666966-2667187 [Sodalis glossinidius str. 'morsitans']
ATGCGGACCTATACCACATCTCAGGCCCGGCAAAATATTGCAGAGGTAATGGAAGCGGCTACGGCTGGTGAGCCTGTAGA
AATAACCCGCCGCGATGGCTCTGCCGCCGTACTTATCAGCCGCGATGATTTCAACACGTGGCAGGAAACAAAGCTGGATG
CTGAATTTGCCGAAATTATGGGGCGGCACGGTTGCACTATTAAGGCGCTGGCCGACAGATGA

Structures

Toxin

• AlphaFold DB: Q2NSN8

Antitoxin

• AlphaFold DB: A0A193QKG1