Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2798523..2800111 Replicon chromosome
Accession NZ_CP082032
Organism Klebsiella pneumoniae strain KP18-2138

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag K6163_RS13905 Protein ID WP_004199851.1
Coordinates 2798523..2799845 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag K6163_RS13910 Protein ID WP_002904790.1
Coordinates 2799845..2800111 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6163_RS13890 2793588..2796089 + 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -
K6163_RS13895 2796077..2797081 + 1005 WP_004199852.1 fimbrial protein -
K6163_RS13900 2797214..2798506 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
K6163_RS13905 2798523..2799845 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
K6163_RS13910 2799845..2800111 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
K6163_RS13915 2800377..2800703 - 327 WP_002904788.1 hydroxyisourate hydrolase -
K6163_RS13920 2800700..2801200 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
K6163_RS13925 2801178..2802557 - 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
K6163_RS13930 2802903..2804057 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
K6163_RS13935 2804038..2804961 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T214043 WP_004199851.1 NZ_CP082032:c2799845-2798523 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T214043 NZ_CP109947:579149-580483 [Pectobacterium cacticida]
ATGCCTCGAACACAACAGCGTTTAGCAATATGGATGAATGGAATCCAAGTGGGATTCTGGGAAAAGATCCGAGGCGAAGA
TAGGTTGCAATACCTTCCCGAATGGATCGCTGATGAACAAGGAAGACCTTTATCGCTTTCTTTGCTTTTCACCCCCGGTA
ATCAGATGTGGCGCGGCAATGTGGTACGCGACTATTTTGATAATTTATTGCCTGACAGCGAAGGTATACGCAGGCGGTTA
GCAACGCGTTACCAGGCTGATAGCCTTGAGCCCTTTGATCTGTTGGCTGAGCTGGGGAGAGACTGTGTTGGCGCAATACA
GTTACTGAATGGTAATGAGGAGCCCGCAGATCTCTTTTCCGTGAATTATCGCCCGCTTTCTGAAGCTGAAATCGCCGCTA
TATTGCGTAATACAACAGCGTCATTGTTGCCAGGTCGGCAGGATGATGCTGACGATGTGCGTTTATCGATTGCCGGTGCG
CAGGAAAAAACGGCTTTACTCTGGCATGAAGGACAATGGTGCTTGCCAGAAGGGAGTACCCCTACGACGCATATTTTCAA
GTTACCACTCGGGCTAGTGGGTAATAGGCAAGCGGATATGAGTACGTCGGTTGAAAATGAATGGCTATGTTCTTTGATCC
TTAAGGAATATGGAATTCCTGTCGCAAAAACACAGATTGCGCAGTTTGAAGATCAGAAAGTATTGGTTGTTGAGCGTTTT
GACAGAAGATGGTCAAGCGATCGGCAATGGATCATTCGCTTGCCACAAGAGGATATGTGTCAGGCTCTGGGGGTTTCCCC
GCTACGAAAATACCAGTCTGATGGGGGGCCAGGGATTTCCGATATTATGGAAATACTGAGTCATTCGGAGCAGGCGGAGC
AGGACAAAGCGCGGTTTTTCAGGGCGCAAATTATTTTCTGGCTGATAGCGGCAACTGATGGACATGCCAAAAATTTCAGT
ATCGCGATTGAGCCACAAGGCCGCTATCACCTTACACCGCTTTATGATGTTTTATCGGCATGGCCGGTCGTTGGCCCACG
TAATAACCAGATTTCCTGGCAAACGTGCACGCTGGCAATGGCCGTTCGCGGTAGCAGTAATTATTACCATCTGTACAGAA
TTCAACGGCGGCATTGGGTCAATCAGGGTGAATTAACCGGTTTGGGCAGGCGACAGGTTGAAGCCATGATGGATGATATT
ATCTCCAGGACACCTGAGGTTATTGAACGTGTATCTGCATTGCTGCCTGAGTCATTCCCACCAGCGCTTGCGGAATGTGT
TTTTGACGGTATGCGACAACAGTGTGGTCGGTTACAAGAATTGCACCGTAAATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT214043 WP_002904790.1 NZ_CP082032:c2800111-2799845 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT214043 NZ_CP109947:578839-579144 [Pectobacterium cacticida]
ATGAATACAGTTTATCCGTTAAAAACCTTGAATCAGTTGCGCCCATTGCTGATTGGCTTTCGTAAGGCGAAGGGGCTGAC
GCAAAAAGACGTGTCTGAACGGTTAGGTGTCACACAGCAAACCTATGCCCGCTTGGAAGCAAATCCTGGCAGTGCCAGTA
TCGAGCGCTTGTTTAAAGTGCTCACCGTTCTGGGGGTTGAGATGGTGCTGTCTTCTGGACCAAACGTACATTTATCTCTG
TCATTCCCAACGATGGAAGAGTCAGAAAAGCCAATAGACTCACCCGCCAGACGGGAAAAATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References